Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fospropofol disodium
Drug ID BADD_D00972
Description Fospropofol is a water soluble prodrug and is converted to propofol in the liver. Fospropofol is a short acting hypnotic/sedative/anesthetic agent. Unlike propofol, does not cause injection-site pain as it is unable to activate TRPA1. FDA approved in December 2008. Fospropofol is a Schedule IV controlled substance in the United States under the Controlled Substances Act.
Indications and Usage For monitored anaesthesia care sedation in patients undergoing diagnostic procedures like bronchoscopy and colonscopy or minor surgical procedures like arthroscopy and bunionectomy.
Marketing Status approved; illicit; investigational
ATC Code Not Available
DrugBank ID DB06716
KEGG ID D04257
MeSH ID C472965
PubChem ID 3038497
TTD Drug ID D02EZM
NDC Product Code 66064-1034
UNII 30868AY0IF
Synonyms fospropofol | Aquavan | Lusedra | fospropofol disodium | methanol, (2,6-bis(1-methylethyl)phenoxy)-, dihydrogen phosphate, disodium salt | GPI 15715 | GPI15715
Chemical Information
Molecular Formula C13H19Na2O5P
CAS Registry Number 258516-87-9
SMILES CC(C)C1=C(C(=CC=C1)C(C)C)OCOP(=O)([O-])[O-].[Na+].[Na+]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Apnoea22.02.01.001--
Blood methanol increased13.17.02.005---
Burning sensation08.01.09.029; 17.02.06.001---
Cough22.02.03.001--
Gastrointestinal disorder07.11.01.001---
Headache17.14.01.001--
Hepatic failure09.01.03.002--
Hypotension24.06.03.002--
Hypoxia22.02.02.003--
Nausea07.01.07.001--
Nervous system disorder17.02.10.001---
Pain08.01.08.004--
Paraesthesia17.02.06.005; 23.03.03.094--
Pruritus23.03.12.001--
Respiratory depression17.02.05.047; 22.02.01.010---
Skin disorder23.03.03.007---
Ventricular tachycardia02.03.04.010--
Vomiting07.01.07.003--
Angiopathy24.03.02.007---
Mediastinal disorder22.09.03.001---
Pulmonary function test decreased13.19.01.001---
Procedural pain08.01.08.009; 12.02.05.007---
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