| Drug Name |
Fexofenadine hydrochloride |
| Drug ID |
BADD_D00894 |
| Description |
Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms.[L4269] It is selective for the H1 receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier[L10779] - this is in contrast to previous first-generation antihistamines, such as [diphenhydramine], which readily bind to off-targets that contribute to side effects such as sedation.[A1452] Fexofenadine is the major active metabolite of [terfenadine][A1495] and is administered as a racemic mixture in which both enantiomers display approximately equivalent antihistamine activity.[L10779] |
| Indications and Usage |
In the United States, fexofenadine is indicated for the symptomatic treatment of allergic rhinitis in patients ≥2 years old and chronic idiopathic urticaria in patients ≥6 months old.[L4269] In Canada, fexofenadine carries the same indications but is approved only for patients ≥12 years old.[L10779] Fexofenadine is also available in combination with [pseudoephedrine] for the symptomatic treatment of season allergic rhinitis in patients ≥12 years old.[L10800] |
| Marketing Status |
approved; investigational |
| ATC Code |
R06AX26 |
| DrugBank ID |
DB00950
|
| KEGG ID |
D00671
|
| MeSH ID |
C093230
|
| PubChem ID |
63002
|
| TTD Drug ID |
D01KPV
|
| NDC Product Code |
53360-1109; 11673-571; 0113-0847; 36800-954; 41167-4121; 49348-968; 55111-782; 55319-917; 57483-230; 61269-527; 62207-766; 0363-0784; 63629-9463; 63868-334; 68001-440; 70000-0586; 12579-188; 17404-0019; 53360-1106; 66577-021; 0113-0571; 36800-761; 37808-392; 41167-4122; 41167-4131; 43598-809; 57483-240; 62011-0413; 83324-009; 12854-915; 46438-0637; 46438-1111; 55111-784; 65372-1167; 41163-571; 49035-784; 53943-392; 55301-847; 56062-847; 57344-292; 66715-9707; 68016-995; 72036-292; 72476-192; 68001-439; 68016-887; 69842-492; 69848-002; 70677-0074; 70677-1009; 53104-7583; 62207-002; 11822-0425; 11822-3698; 41163-292; 41167-4124; 50090-1234; 63940-768; 64679-982; 68210-0122; 68210-4090; 69842-052; 71205-739; 72036-191; 73581-103; 46438-0638; 65862-966; 37808-391; 37808-847; 55910-111; 63868-025; 63981-847; 68196-107; 68210-2210; 71335-0721; 72476-847; 73581-011; 0904-6711; 0480-7253; 12579-182; 51927-0016; 55111-023; 55111-783; 71796-015; 82348-104; 54257-702; 64679-987; 68998-292; 43598-577; 44657-0078; 21130-784; 41167-4120; 41167-4232; 46122-462; 62207-765; 68071-5191; 68391-847; 70518-2971; 70692-134; 65015-894; 65096-0103; 30142-878; 37808-571; 41167-4126; 41167-4244; 43598-936; 45802-847; 49035-366; 51672-2119; 55910-609; 0363-0783; 70000-0361; 72288-847; 0480-7252; 12579-189; 46438-0107; 51927-0044; 58175-0616; 65977-0060; 11822-0571; 36800-319; 36800-653; 36800-691; 41250-784; 51316-800; 51672-2121; 62011-0409; 62756-545; 64679-744; 67751-033; 71309-091; 71335-0483; 71610-292; 79481-0847; 80159-112; 46438-0651; 51686-0001; 10202-107; 10202-229; 62993-0809; 77777-113; 11673-617; 51660-998; 54257-170; 55910-571 |
| UNII |
2S068B75ZU
|
| Synonyms |
fexofenadine | alpha-(4-(1-carboxy-1-methylethyl)phenyl)-4-hydroxydiphenylmethyl-1-piperidinebutanol | fexofenadine hydrochloride | MDL 16.455 | MDL-16455 | MDL 16455 | Allegra | Telfast | MDL 16,455A |
