Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Esmolol
Drug ID BADD_D00813
Description Esmolol, commonly marketed under the trade name Brevibloc, is a cardioselective beta-1 receptor blocker. It has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses. It works by blocking beta-adrenergic receptors in the heart, which leads to decreased force and rate of heart contractions. Esmolol prevents the action of two naturally occurring substances: epinephrine and norepinephrine.
Indications and Usage For the rapid control of ventricular rate in patients with atrial fibrillation or atrial flutter in perioperative, postoperative, or other emergent circumstances where short term control of ventricular rate with a short-acting agent is desirable. Also used in noncompensatory sinus tachycardia where the rapid heart rate requires specific intervention.
Marketing Status approved
ATC Code C07AB09
DrugBank ID DB00187
KEGG ID D07916
MeSH ID C036604
PubChem ID 59768
TTD Drug ID D03XTC
NDC Product Code Not Available
UNII MDY902UXSR
Synonyms esmolol | Brevibloc | esmolol hydrochloride | ASL 8052 | ASL-8052
Chemical Information
Molecular Formula C16H25NO4
CAS Registry Number 81147-92-4
SMILES CC(C)NCC(COC1=CC=C(C=C1)CCC(=O)OC)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Thrombophlebitis24.01.02.001---
Urethral disorder20.07.01.002---
Urinary retention20.02.02.011--
Urinary tract disorder20.08.01.001---
Urticaria10.01.06.001; 23.04.02.001--
Ventricular extrasystoles02.03.04.007---
Ventricular fibrillation02.03.04.008--
Visual impairment06.02.10.013---
Vomiting07.01.07.003--
Wheezing22.03.01.009--
Acute coronary syndrome02.02.02.015; 24.04.04.011---
Sticky skin23.03.03.019---
Infusion site pain08.02.05.014; 12.07.05.002---
Infusion site reaction08.02.05.005; 12.07.05.006---
Pulseless electrical activity02.03.04.020---
Angiopathy24.03.02.007---
Induration08.01.03.020---
Cardiac disorder02.11.01.003---
Inflammation08.01.05.007; 10.02.01.089---
Mental disorder19.07.01.002---
Decreased appetite08.01.09.028; 14.03.01.005--
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