Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ergotamine tartrate
Drug ID BADD_D00797
Description A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders.
Indications and Usage For use as therapy to abort or prevent vascular headache, e.g., migraine, migraine variants, or so called "histaminic cephalalgia".
Marketing Status approved
ATC Code N02CA02
DrugBank ID DB00696
KEGG ID D00679
MeSH ID D004878
PubChem ID 9787
TTD Drug ID D01TSI
NDC Product Code 38779-0219; 47848-001; 55486-1581; 70720-120
UNII MRU5XH3B48
Synonyms Ergotamine | Ergomar | Ergostat | Ergotamine Tartrate | Tartrate, Ergotamine | Ergotamine Tartrate (2:1) | Ergotaminine | Ergo-Kranit | Ergo Kranit | Lingraine | Cornutamine | Ergo Sanol | Ergodryl Mono | Mono, Ergodryl | Gynergen
Chemical Information
Molecular Formula C70H76N10O16
CAS Registry Number 379-79-3
SMILES CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C 6=C5)C.CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC (=C78)C6=C5)C.C(C(C(=O)O)O)(C(=O)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Asthenia08.01.01.001---
Bradycardia02.03.02.002---
Chest discomfort02.02.02.009; 08.01.08.019; 22.12.02.002---
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Cyanosis02.11.04.004; 22.02.02.007; 23.06.04.005; 24.03.01.007--
Electrocardiogram abnormal13.14.05.001---
Fibrosis08.03.01.001---
Gangrene11.02.01.003; 23.06.06.001; 24.04.05.003---
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023; 23.03.03.081---
Myalgia15.05.02.001--
Nausea07.01.07.001--
Paraesthesia17.02.06.005; 23.03.03.094--
Peripheral coldness08.01.09.010; 23.06.04.008; 24.04.03.006---
Pruritus23.03.12.001--
Pulse abnormal13.14.04.004---
Tachycardia02.03.02.007---
Vertigo04.04.01.003; 17.02.12.002--
Vomiting07.01.07.003--
Localised oedema02.05.04.006; 08.01.07.011; 14.05.06.009--
Ischaemia24.04.02.004---
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