Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Eltrombopag olamine
Drug ID BADD_D00760
Description Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood. Eltrombopag has also been recently approved (late 2012) for the treatment of thrombocytopenia (low blood platelet counts) in patients with chronic hepatitis C to allow them to initiate and maintain interferon-based therapy.
Indications and Usage Thrombopoietin receptor agonists are pharmaceutical agents that stimulate platelet production in the bone marrow. In this, they differ from the previously discussed agents that act by attempting to curtail platelet destruction.
Marketing Status approved
ATC Code B02BX05
DrugBank ID DB06210
KEGG ID D03978
MeSH ID C520809
PubChem ID 135449331
TTD Drug ID D00PEH
NDC Product Code 81719-004; 0078-0687; 0078-0697; 62207-971; 0078-0685; 61187-000; 0078-0684; 0078-0972; 11722-051; 52076-6274; 63379-089; 63379-090; 81719-005; 59651-620; 81719-006; 65977-0097; 14501-0018; 81719-007; 0078-0686
UNII 4U07F515LG
Synonyms eltrombopag | Revolade | SB-497 115 | Promacta
Chemical Information
Molecular Formula C29H36N6O6
CAS Registry Number 496775-62-3
SMILES CC1=C(C=C(C=C1)N2C(=O)C(=C(N2)C)N=NC3=CC=CC(=C3O)C4=CC(=CC=C4)C(=O)O)C.C(CO)N.C( CO)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Alanine aminotransferase increased13.03.04.005--
Alopecia23.02.02.001--
Anaemia01.03.02.001--
Aspartate aminotransferase increased13.03.04.011--
Asthenia08.01.01.001---
Back pain15.03.04.005--
Cataract06.06.01.001--
Chills08.01.09.001; 15.05.03.016--
Cough22.02.03.001--
Diarrhoea07.02.01.001--
Dry mouth07.06.01.002--
Fatigue08.01.01.002--
Headache17.14.01.001--
Hyperbilirubinaemia01.06.04.003; 09.01.01.003; 14.11.01.010---
Influenza11.05.03.001; 22.07.02.001---
Influenza like illness08.01.03.010--
Insomnia17.15.03.002; 19.02.01.002--
Liver function test abnormal13.03.04.030---
Musculoskeletal pain15.03.04.007--
Myalgia15.05.02.001--
Nausea07.01.07.001--
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.011--
Paraesthesia17.02.06.005; 23.03.03.094--
Pharyngitis07.05.07.004; 11.01.13.003; 22.07.03.004--
Portal vein thrombosis09.01.06.007; 24.01.03.003--
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
Rash23.03.13.001---
Thrombotic thrombocytopenic purpura01.08.01.005; 23.06.01.011; 24.07.06.014--
Upper respiratory tract infection11.01.13.009; 22.07.03.011--
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