Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dyphylline
Drug ID BADD_D00737
Description Dyphylline is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis.
Indications and Usage For relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema.
Marketing Status approved
ATC Code R03DA01
DrugBank ID DB00651
KEGG ID D00691
MeSH ID D004400
PubChem ID 3182
TTD Drug ID D02PWM
NDC Product Code Not Available
UNII 263T0E9RR9
Synonyms Dyphylline | Diphylline | Dihydroxypropyltheophylline | Diprophylline | Lufyllin | Dilin | Neothylline | Dylix
Chemical Information
Molecular Formula C10H14N4O4
CAS Registry Number 479-18-5
SMILES CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(CO)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain upper07.01.05.003--
Agitation17.02.05.012; 19.06.02.001--
Albuminuria20.02.01.001---
Circulatory collapse24.06.02.001---
Diarrhoea07.02.01.001--
Extrasystoles02.03.02.003---
Flushing08.01.03.025; 23.06.05.003; 24.03.01.002--
Generalised tonic-clonic seizure17.12.01.002---
Haematemesis07.12.02.002; 24.07.02.011---
Haematuria20.02.01.006; 21.10.01.018; 24.07.01.047--
Headache17.14.01.001--
Hyperglycaemia05.06.02.002; 14.06.02.002--
Hypotension24.06.03.002--
Insomnia17.15.03.002; 19.02.01.002--
Irritability08.01.03.011; 19.04.02.013--
Muscle twitching15.05.03.005---
Nausea07.01.07.001--
Palpitations02.11.04.012--
Polyuria20.02.03.002---
Restlessness17.02.05.021; 19.11.02.002--
Seizure17.12.03.001--
Shock24.06.02.002---
Tachycardia02.03.02.007---
Tachypnoea22.02.01.014---
Ventricular arrhythmia02.03.04.006--
Vomiting07.01.07.003--
Inappropriate antidiuretic hormone secretion05.03.03.001; 14.05.07.001---
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ADReCS-Target
Drug Name ADR Term Target
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