Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Doxapram hydrochloride
Drug ID BADD_D00717
Description A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
Indications and Usage For use as a temporary measure in hospitalized patients with acute respiratory insufficiency superimposed on chronic obstructive pulmonary disease.
Marketing Status approved; vet_approved
ATC Code R07AB01
DrugBank ID DB00561
KEGG ID D01872
MeSH ID D004315
PubChem ID 64647
TTD Drug ID D0M7BT
NDC Product Code 51662-1404; 0641-6018
UNII P5RU6UOQ5Y
Synonyms Doxapram | Dopram | Doxapram Hydrochloride | Hydrochloride, Doxapram | Docatone
Chemical Information
Molecular Formula C24H31ClN2O2
CAS Registry Number 113-07-5
SMILES CCN1CC(C(C1=O)(C2=CC=CC=C2)C3=CC=CC=C3)CCN4CCOCC4.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Albuminuria20.02.01.001---
Anxiety19.06.02.002--
Arrhythmia02.03.02.001---
Blood pressure increased13.14.03.005---
Blood urea increased13.13.01.006---
Bronchospasm10.01.03.012; 22.03.01.004--
Burning sensation08.01.09.029; 17.02.06.001---
Chest discomfort02.02.02.009; 08.01.08.019; 22.12.02.002---
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Clonus17.02.05.002---
Cough22.02.03.001--
Defaecation urgency07.02.04.001---
Diarrhoea07.02.01.001--
Disorientation17.02.05.015; 19.13.01.002---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dyskinesia17.01.02.006--
Dyspnoea02.11.05.003; 22.02.01.004--
Electrocardiogram T wave amplitude decreased13.14.05.006---
Extensor plantar response17.02.01.005---
Feeling hot08.01.09.009---
Flushing08.01.03.025; 23.06.05.003; 24.03.01.002--
Haematocrit13.01.05.017---
Haemoglobin decreased13.01.05.003---
Haemolysis01.06.04.002--
Hallucination19.10.04.003--
Headache17.14.01.001--
Heart rate abnormal13.14.04.006---
Hiccups07.01.06.009; 22.12.01.001--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hyperreflexia17.02.01.002---
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