Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Demeclocycline hydrochloride
Drug ID BADD_D00606
Description A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
Indications and Usage Used primarily to treat Lyme disease, acne, and bronchitis. Also indicated (but rarely used) to treat urinary tract infections, gum disease, malaria, and other bacterial infections such as gonorrhea and chlamydia. One of its other registered uses is the treatment of hyponatremia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) where fluid restriction alone has been ineffective.
Marketing Status approved
ATC Code J01AA01; D06AA01
DrugBank ID DB00618
KEGG ID D00290
MeSH ID D003707
PubChem ID 54686764
TTD Drug ID D0R9WP
NDC Product Code 24658-710; 62584-159; 62584-163; 24658-711; 42806-143; 52972-0030; 42806-144
UNII 29O079NTYT
Synonyms Demeclocycline | Demethylchlortetracycline | Declomycin | Lédermycine | Ledermycin | Demeclocycline, Calcium (1:1) Salt | Demeclocycline Monohydrochloride | Monohydrochloride, Demeclocycline | Demeclocycline, 4-epimer | Demeclocycline, Calcium (1:2) Salt | Demeclocycline Hydrochloride | Hydrochloride, Demeclocycline
Chemical Information
Molecular Formula C21H22Cl2N2O8
CAS Registry Number 64-73-3
SMILES CN(C)C1C2CC3C(C4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)Cl)O.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Arthralgia15.01.02.001--
Balanoposthitis21.09.03.001---
Blister12.01.06.002; 23.03.01.001---
Blood urea increased13.13.01.006---
Dermatitis exfoliative10.01.01.004; 23.03.07.001--
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dysphagia07.01.06.003--
Enterocolitis07.08.03.003--
Eosinophilia01.02.04.001--
Erythema multiforme10.01.03.015; 23.03.01.003--
Fontanelle bulging17.02.05.006; 18.04.04.001---
Glossitis07.14.01.001---
Haemolytic anaemia01.06.03.002---
Headache17.14.01.001--
Henoch-Schonlein purpura01.01.04.001; 10.02.02.004; 23.06.01.002; 24.07.06.003---
Hepatic failure09.01.03.002--
Hepatitis09.01.07.004---
Hepatotoxicity09.01.07.009; 12.03.01.008---
Lung infiltration22.01.02.004---
Myasthenic syndrome10.04.05.005; 15.05.08.003; 16.32.01.002; 17.05.04.004---
Nausea07.01.07.001--
Nephrogenic diabetes insipidus14.05.07.002; 20.05.03.010---
Neutropenia01.02.03.004---
Pancreatitis07.18.01.001--
Pericarditis02.06.02.001--
Photosensitivity reaction23.03.09.003--
Rash erythematous23.03.13.029---
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