Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dacarbazine
Drug ID BADD_D00568
Description An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma.
Indications and Usage For the treatment of metastatic malignant melanoma. In addition, dacarbazine is also indicated for Hodgkin's disease as a secondary-line therapy when used in combination with other antineoplastic agents.
Marketing Status approved; investigational
ATC Code L01AX04
DrugBank ID DB00851
KEGG ID D00288
MeSH ID D003606
PubChem ID 2942
TTD Drug ID D0Y7ZU
NDC Product Code 42973-149; 63323-128; 0143-9245; 0703-5075; 54875-0003; 63323-127
UNII 7GR28W0FJI
Synonyms Dacarbazine | Dimethyl Imidazole Carboxamide | Carboxamide, Dimethyl Imidazole | Imidazole Carboxamide, Dimethyl | DTIC | ICDT | Decarbazine | 5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide | DIC | Dimethyl Triazeno Imidazole Carboxamide | NSC-45388 | NSC 45388 | NSC45388 | DTIC-Dome | DTIC Dome | DTICDome | Biocarbazine | Deticene
Chemical Information
Molecular Formula C6H10N6O
CAS Registry Number 4342-03-4
SMILES CN(C)N=NC1=C(NC=N1)C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Premature menopause05.05.01.016; 21.02.02.0040.000112%
Proteinuria20.02.01.0110.000112%
Pyrexia08.05.02.0030.000280%
Rash23.03.13.0010.000112%-
Rash erythematous23.03.13.029---
Rash maculo-papular23.03.13.0040.000112%
Seizure17.12.03.001--
Stomatitis07.05.06.005--
Tachycardia02.03.02.0070.000280%-
Thrombocytopenia01.08.01.0020.000302%-
Thrombotic microangiopathy01.01.02.006; 20.01.07.004; 24.01.01.0130.000168%-
Urticaria10.01.06.001; 23.04.02.001--
Venoocclusive liver disease09.01.06.002; 12.02.09.039; 24.04.07.002--
Vision blurred06.02.06.007; 17.17.01.010--
Vomiting07.01.07.0030.000224%
Malignant neoplasm progression16.16.01.0050.000336%-
Musculoskeletal discomfort15.03.04.001---
Vascular occlusion24.04.02.015---
Hepatic vein occlusion09.01.06.011; 24.04.07.005---
Hepatic enzyme increased13.03.04.028---
Neoplasm progression16.16.02.0050.000168%-
Decreased appetite08.01.09.028; 14.03.01.005--
Renal function test abnormal13.13.01.012---
Ill-defined disorder08.01.03.049---
Disease progression08.01.03.0380.000168%
Venoocclusive disease24.03.02.016---
Renal impairment20.01.03.0100.000112%-
Bone marrow failure01.03.03.005--
Acute kidney injury20.01.03.0160.000112%
Foetal growth restriction18.03.01.0020.000112%
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ADReCS-Target
Drug Name ADR Term Target
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