Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Ceftriaxone sodium
Drug ID BADD_D00406
Description Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic.[A215582] It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges[A215582], eyes[A215647], and inner ear[A215627]. Ceftriaxone has broader and stronger gram-negative coverage then first or second-generation cephalosporins, but worse activity against methicillin-susceptible S.aureus. Ceftriaxone is a commonly used antimicrobial due to its good activity against multi-drug resistant Enterobacteriaceae, its relatively safe adverse effect profile, and its long half-life which allows for the convenience of daily or twice-daily dosing.[A215582]
Indications and Usage For the treatment of the infections (respiratory, skin, soft tissue, UTI, ENT) caused by S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph
Marketing Status Prescription; Discontinued
ATC Code J01DD04
DrugBank ID DB01212
KEGG ID D00924
MeSH ID D002443
PubChem ID 9570985
TTD Drug ID D07ACT
NDC Product Code 50090-2444; 60505-6151; 50090-0944; 0409-7338; 0409-7335; 50090-3810; 67184-1007; 67184-1006; 50090-4978; 25021-108; 70518-3099; 50090-3838; 38779-2383; 0409-7332; 0781-3209; 71205-545; 67184-1008; 0409-7334; 60505-6152; 70518-2499; 70518-0168; 68071-4682; 50090-3447; 0781-3210; 67184-1005; 0781-3206; 0338-5003; 0781-3207; 0338-5002; 70518-2301; 50090-1875; 0409-7333; 60505-6149; 0781-3208; 0409-7337; 51065-004; 50090-4689; 0409-7336; 60505-6150; 60505-6148; 66288-6100
Synonyms Ceftriaxone | Ceftriaxon | Cefatriaxone | Ceftriaxone, Disodium Salt, Hemiheptahydrate | Ceftrex | Ceftriaxon Curamed | Ceftriaxon Hexal | Ceftriaxona Andreu | Ceftriaxona LDP Torlan | Ceftriaxone Irex | Ceftriaxone Sodium | Ceftriaxone Sodium, Anhydrous | Anhydrous Ceftriaxone Sodium | Lendacin | Longacef | Longaceph | Ro13-9904 | Ro13 9904 | Ro139904 | Ro-13-9904 | Ro 13-9904 | Ro 13 9904 | Ro 139904 | Rocephin | Rocefalin | Rocephine | Rocefin | Tacex | Terbac | Ceftriaxone, Disodium Salt | Benaxona | Cefaxona
Chemical Information
Molecular Formula C18H16N8Na2O7S3
CAS Registry Number 73384-59-5
SMILES CN1C(=NC(=O)C(=N1)[O-])SCC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)[O-] .[Na+].[Na+]
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase13.03.01.031--Not Available
Alveolitis allergic10.01.03.008; 22.01.01.002--Not Available
Anaemia01.03.02.001--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Anaphylactoid reaction10.01.07.003; 24.06.03.007--Not Available
Aplastic anaemia01.03.03.002--Not Available
Aspartate aminotransferase increased13.03.01.006--
Basophilia01.02.01.009--Not Available
Blood bilirubin increased13.03.01.008--
Blood creatinine increased13.13.01.004--
Blood lactate dehydrogenase increased13.04.02.002--
Blood urea increased13.13.01.006--Not Available
Bronchospasm10.01.03.012; 22.03.01.004--
Chills08.01.09.001; 15.05.03.016--
Cholelithiasis09.03.01.002--Not Available
Cholestasis09.01.01.001--Not Available
Coagulopathy01.01.02.001--Not Available
Colitis07.08.01.001--
Complications of transplanted liver09.01.08.011; 12.02.09.014--Not Available
Coombs direct test positive13.01.01.001--Not Available
Dermatitis allergic10.01.03.014; 23.03.04.003--Not Available
Diarrhoea07.02.01.001--
Dizziness02.01.02.004; 17.02.05.003; 24.06.02.007--
Dysgeusia07.14.03.001; 17.02.07.003--
Dyspepsia07.01.02.001--
Eosinophilia01.02.04.001--
Epistaxis22.04.03.001; 24.07.01.005--
Feeling hot08.01.09.009--Not Available
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