Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Benzoyl peroxide
Drug ID BADD_D00241
Description Benzoyl peroxide is a commonly used drug in topical treatments for acne.[L33249,L33264,L33269,L33299,L33314] It has been formulated as products with either a single active ingredient,[L33249,L33299] or with [erythromycin],[L33264] [clindamycin],[L33269] or [adapalene].[L33314] After administration, the peroxide bond is cleaved, allowing benzoyloxy radicals to nonspecifically interact with proteins.[A18903,A233859] This treatment decreases keratin and sebum around follicles, as well as increasing turnover of epithelial cells.[A234059,A234064,A234069] Benzoyl peroxide, in combination with erythromycin, was granted FDA approval on 26 October 1984.[L33264]
Indications and Usage Benzoyl peroxide is formulated with antibiotics such as [erythromycin][L33264] and [clindamycin][L33269] for the treatment of acne vulgaris. Benzoyl peroxide is formulated as a number of topical products for the treatment of acne.[L33249, L33299] Benzoyl peroxide is also indicated in combination with [tretinoin] for the treatment of acne vulgaris in patients aged nine years and older.[L34869]
Marketing Status approved
ATC Code D10AE01
DrugBank ID DB09096
KEGG ID D03093
MeSH ID D001585
PubChem ID 7187
TTD Drug ID D04DXN
NDC Product Code 73010-900; 82172-230; 51927-3085; 10742-1205; 10742-1397; 10742-8304; 10742-8353; 10742-8356; 21130-730; 24470-901; 42192-161; 45802-318; 51316-048; 67234-035; 69968-0026; 70162-103; 71399-9236; 71399-9474; 71421-101; 71792-101; 71819-011; 71819-013; 11410-011; 11673-152; 14222-1610; 41250-229; 41250-348; 45802-216; 49035-264; 49967-238; 50066-052; 50090-1720; 50594-229; 55621-017; 0316-0264; 0363-0264; 0363-0467; 65113-2372; 67402-021; 68071-2307; 68343-123; 70162-102; 0536-1056; 70707-155; 71397-821; 76144-610; 76162-264; 78518-295; 80861-006; 81136-023; 0869-0264; 10742-1201; 11090-223; 11118-0264; 14222-1600; 39765-034; 41250-567; 49825-129; 51326-112; 58400-001; 0299-4125; 0316-0228; 59958-402; 69748-641; 69968-0043; 0536-1259; 71131-100; 71804-853; 0299-5890; 59958-401; 0363-1522; 63550-193; 64760-712; 65113-2373; 69842-637; 69842-646; 69968-0212; 0536-1261; 70707-101; 70707-151; 70707-211; 77924-002; 79481-0023; 80861-003; 82575-122; 82746-320; 47643-002; 10742-8397; 11410-005; 14222-1620; 24470-900; 0187-0194; 51316-047; 0299-4137; 0363-0116; 0363-0266; 62032-611; 63824-437; 63824-438; 69842-023; 70707-711; 71397-822; 72288-229; 72288-264; 73246-001; 10742-1313; 10742-8293; 11410-012; 11410-046; 24470-911; 30142-264; 35573-454; 41250-264; 42546-016; 0187-0201; 57627-202; 0299-4606; 0363-0137; 67405-825; 68062-9107; 68062-9109; 69842-571; 69968-0720; 0536-1058; 70764-106; 71399-9478; 71804-852; 71817-858; 80861-010; 80861-013; 80861-112; 10738-034; 10742-1202; 11410-040; 11673-149; 11822-6184; 30142-877; 35192-017; 35573-453; 43479-105; 45802-280; 49527-997; 51326-113; 0295-0010; 0363-0256; 62742-4212; 63824-433; 0536-1055; 70764-107; 71421-102; 83101-004; 10742-8355; 10812-975; 42192-163; 42851-087; 49035-132; 49035-829; 51326-111; 51531-9071; 52063-709; 58400-009; 0363-0229; 62742-4075; 67226-2050; 69968-0164; 69968-0653; 0536-1057; 0536-1351; 70707-200; 70707-212; 72288-525; 73350-105; 76144-611; 76162-229; 78518-013; 79903-061; 47643-003; 10742-1301; 10742-1314; 10742-8354; 68634-004; 42192-162; 45802-308; 49035-229; 50090-1792; 51326-412; 55910-264; 0316-0227; 62742-4208; 64760-732; 69842-081; 69842-137; 0536-1129; 71295-102; 71804-230; 72957-001; 76458-333; 80861-002; 47643-001; 10742-1203; 10742-1206; 14222-2120; 41250-347; 53755-392; 0363-0153; 63940-063; 64760-704; 64760-776; 67405-830; 68634-068; 68726-168; 69842-076; 70707-152; 71295-101; 71399-9234; 71687-0011; 72288-526; 72811-137; 73010-127; 78863-1180; 79481-0022; 0869-0229; 17129-002; 11673-088; 11822-7701; 45802-101; 49967-076; 56152-4009; 56152-4012; 58400-003
UNII W9WZN9A0GM
Synonyms Benzoyl Peroxide | Peroxide, Benzoyl | Diphenylglyoxal Superoxide | Superoxide, Diphenylglyoxal | Benzoyl Superoxide | Superoxide, Benzoyl | Dibenzoyl Peroxide | Peroxide, Dibenzoyl | PanOxyl
Chemical Information
Molecular Formula C14H10O4
CAS Registry Number 94-36-0
SMILES C1=CC=C(C=C1)C(=O)OOC(=O)C2=CC=CC=C2
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acne23.02.01.001---
Anaphylactic reaction10.01.07.001; 24.06.03.0060.000599%
Anaphylactic shock10.01.07.002; 24.06.02.004---
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.0010.000599%-
Application site erythema08.02.01.001; 12.07.01.001; 23.03.06.0050.001397%-
Application site irritation08.02.01.003; 12.07.01.003---
Application site pain08.02.01.004; 12.07.01.0040.000399%-
Application site pruritus08.02.01.005; 12.07.01.005; 23.03.12.0040.000599%-
Application site rash08.02.01.016; 12.07.01.016; 23.03.13.008---
Application site reaction08.02.01.006; 12.07.01.006---
Asthenia08.01.01.001---
Burning sensation08.01.09.029; 17.02.06.001---
Cough22.02.03.0010.000878%
Dermatitis23.03.04.002---
Dermatitis allergic10.01.03.014; 23.03.04.0030.000599%-
Dermatitis bullous23.03.01.002--
Dermatitis contact10.01.01.003; 12.03.01.040; 23.03.04.0040.000798%-
Drug ineffective08.06.01.0060.001556%-
Dry skin23.03.03.0010.002035%
Dyspnoea02.11.05.003; 22.02.01.0040.000399%
Erythema23.03.06.0010.002155%-
Erythema multiforme10.01.03.015; 23.03.01.0030.000399%
Erythema of eyelid06.04.04.003; 23.03.06.0060.000399%-
Eye swelling06.08.03.003---
Face oedema08.01.07.003; 10.01.05.002; 23.04.01.0040.000399%
Feeling hot08.01.09.009---
Hypersensitivity10.01.03.0030.000798%
Hypoaesthesia17.02.06.023; 23.03.03.081---
Hypotension24.06.03.002--
Immune system disorder10.02.01.001---
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