Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apomorphine
Drug ID BADD_D00152
Description Apomorphine is a non-ergoline dopamine D2 agonist indicated to treat hypomobility associated with Parkinson's. It was first synthesized in 1845 and first used in Parkinson's disease in 1884.[A203618] Apomorphine has also been investigated as an emetic, a sedative, a treatment for alcoholism, and a treatment of other movement disorders.[A203597,A203618] Apomorphine was granted FDA approval on 20 April 2004.[L13919]
Indications and Usage For the acute, intermittent treatment of hypomobility, off episodes (end-of-dose wearing off and unpredictable on/off episodes) associated with advanced Parkinson's disease.
Marketing Status Prescription; Discontinued
ATC Code G04BE07; N04BC07
DrugBank ID DB00714
KEGG ID D07460
MeSH ID D001058
PubChem ID 6005
TTD Drug ID D0H6QU
NDC Product Code Not Available
Synonyms Apomorphine | Apomorphine Hydrochloride, Anhydrous | Apomorphine Hydrochloride Anhydrous | Apomorphine Hydrochloride | Apomorphin-Teclapharm | Apomorphin Teclapharm | Apomorphine Hydrochloride, Hemihydrate | Apokinon | Apomorphine Chloride | Britaject
Chemical Information
Molecular Formula C17H17NO2
CAS Registry Number 58-00-4
SMILES CN1CCC2=C3C1CC4=C(C3=CC=C2)C(=C(C=C4)O)O
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.001273%Not Available
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.0030.000849%
Agitation17.02.05.012; 19.06.02.0010.001273%
Altered state of consciousness17.02.04.001; 19.07.01.0030.000849%Not Available
Anaemia01.03.02.001--
Angina pectoris02.02.02.002; 24.04.04.002--
Anxiety19.06.02.002--
Arthralgia15.01.02.001--
Asthenia08.01.01.0010.002547%Not Available
Back pain15.03.04.005--
Blood glucose decreased13.02.02.0010.000849%Not Available
Blood pressure decreased13.14.03.0020.001273%Not Available
Bradycardia02.03.02.0020.000849%Not Available
Cardiac arrest02.03.04.0010.000221%
Cardiac failure congestive02.05.01.002--Not Available
Cerebral haemorrhage17.08.01.003; 24.07.04.0010.000221%Not Available
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Chest pain02.02.02.011; 08.01.08.002; 22.02.08.0030.001698%Not Available
Coma17.02.09.0010.000849%Not Available
Completed suicide08.04.01.010; 19.12.01.0010.000221%Not Available
Confusional state17.02.03.005; 19.13.01.0010.001698%
Constipation07.02.02.001--
Cough22.02.03.001--
Cystitis11.01.14.001; 20.03.02.0020.001273%
Death08.04.01.0010.002215%
Dehydration14.05.05.001--
Depression19.15.01.0010.001273%
Diarrhoea07.02.01.001--
Dizziness02.01.02.004; 17.02.05.003; 24.06.02.0070.004669%
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ADReCS-Target
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