Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alogliptin benzoate
Drug ID BADD_D00080
Description Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25, 2013.
Indications and Usage Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Marketing Status Prescription
ATC Code A10BH04
DrugBank ID DB06203
KEGG ID D06553
MeSH ID C520853
PubChem ID 16088021
TTD Drug ID D0NJ5H
NDC Product Code 14445-016; 66039-924; 69037-0024; 14501-0024
Synonyms alogliptin | 2-((6-((3R)-3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl) benzonitrile | nesina | SYR 322 | SYR322 | SYR-322
Chemical Information
Molecular Formula C25H27N5O4
CAS Registry Number 850649-62-6
SMILES CN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCCC(C3)N.C1=CC=C(C=C1)C(=O)O
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acute hepatic failure09.01.03.001--Not Available
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Angioedema10.01.05.009; 23.04.01.001--Not Available
Arthralgia15.01.02.001--
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Hypoglycaemia05.06.03.001; 14.06.03.001--
Nasopharyngitis11.01.13.002; 22.07.03.002--Not Available
Pancreatitis07.18.01.001--
Pancreatitis acute07.18.01.002--Not Available
Rash23.03.13.001--Not Available
Stevens-Johnson syndrome10.01.03.020; 11.07.01.005; 12.03.01.014; 23.03.01.007--
Upper respiratory tract infection11.01.13.009; 22.07.03.011--
Urticaria10.01.06.001; 23.04.02.001--
Hepatic enzyme increased13.03.01.019--Not Available
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