Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alogliptin
Drug ID BADD_D00079
Description Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25, 2013.
Indications and Usage Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Marketing Status Prescription
ATC Code A10BH04
DrugBank ID DB06203
KEGG ID D06553
MeSH ID C520853
PubChem ID 11450633
TTD Drug ID D0NJ5H
NDC Product Code 65392-2813; 64764-625; 11532-7002; 71610-300; 66332-7003; 45802-150; 64764-250; 64764-125; 45802-103; 45802-087; 11532-7003; 50090-5574; 11532-7001; 66332-7002; 66332-7001
Synonyms alogliptin | 2-((6-((3R)-3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl) benzonitrile | nesina | SYR 322 | SYR322 | SYR-322
Chemical Information
Molecular Formula C18H21N5O2
CAS Registry Number 850649-61-5
SMILES CN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCCC(C3)N
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dermatitis23.03.04.002--Not Available
Diabetes mellitus05.06.01.001; 14.06.01.0010.000300%Not Available
Diabetic neuropathy05.07.04.003; 14.07.04.003; 17.09.04.0020.000200%Not Available
Diarrhoea07.02.01.001--
Dizziness02.01.02.004; 17.02.05.003; 24.06.02.007--
Drug eruption08.01.06.015; 10.01.01.005; 23.03.05.0010.000601%Not Available
Drug hypersensitivity10.01.01.001--Not Available
Dyspnoea exertional02.01.03.003; 22.02.01.0050.000200%Not Available
Eczema23.03.04.0060.000200%
Enterocolitis07.08.03.0030.000300%
Erythema23.03.06.0010.000300%Not Available
Erythema multiforme10.01.03.015; 23.03.01.0030.000501%
Feeling abnormal08.01.09.0140.000300%Not Available
Flatulence07.01.04.0020.000200%
Fracture12.04.02.001; 15.08.02.0010.000200%
Gastric cancer07.21.02.001; 16.13.03.0010.000078%Not Available
Gastrooesophageal reflux disease07.02.02.0030.000300%
Gastrointestinal haemorrhage07.12.02.001; 24.07.02.009--Not Available
Glycosylated haemoglobin increased13.02.02.0050.000200%Not Available
Haematuria20.02.01.006; 24.07.01.0470.000200%
Headache17.14.01.001--
Heart rate increased13.14.04.0020.000200%Not Available
Hepatic function abnormal09.01.02.0010.000701%Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypoglycaemia05.06.03.001; 14.06.03.0010.000701%
Hyponatraemia14.05.04.0020.000200%
Ileus07.13.01.0010.000501%
Infection11.01.08.0020.000052%Not Available
Interstitial lung disease10.02.01.033; 22.01.02.0030.001402%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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