Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alfuzosin
Drug ID BADD_D00069
Description Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to 80%-90% of those over 70.[A228483] Alfuzosin is an alpha-1 adrenergic blocker used in the symptomatic treatment of BPH that works by relaxing the muscles in the prostate and bladder neck.[L31593] It was initially approved by the FDA in 2003 and is marketed by several pharmaceutical companies.[L9251]
Indications and Usage For the reduction of urinary obstruction and relief of associated manifestations (eg. sensation of incomplete bladder emptying or straining, urgency, interrupted or weak stream) in patients with symptomatic beningn prostatic hyperplasia.
Marketing Status Prescription; Discontinued
ATC Code G04CA01
DrugBank ID DB00346
KEGG ID D07124
MeSH ID C047638
PubChem ID 2092
TTD Drug ID D09MWJ
NDC Product Code Not Available
Synonyms alfuzosin | alphuzosine | N-(3-((4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)tetrahydro-2-furancarboxamide | alfusozine | alfuzosin hydrochloride | UroXatral | Benestan | Urion | Xatral | Alfetim
Chemical Information
Molecular Formula C19H27N5O4
CAS Registry Number 81403-80-7
SMILES CN(CCCNC(=O)C1CCCO1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Flushing08.01.03.025; 23.06.05.003; 24.03.01.002--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Headache17.14.01.001--
Hepatocellular injury09.01.07.008--Not Available
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hypotension24.06.03.002--
Infection11.01.08.002--Not Available
Influenza like illness08.01.03.010--
Injury12.01.08.004--Not Available
Jaundice01.06.04.004; 09.01.01.004; 23.03.03.030--Not Available
Laryngitis11.01.13.001; 22.07.03.001--
Loss of consciousness17.02.04.004--Not Available
Malaise08.01.01.003--
Miosis06.05.03.003; 17.02.11.002--Not Available
Nausea07.01.07.001--
Nephrolithiasis20.04.01.002--
Nervous system disorder17.02.10.001--Not Available
Neuralgia17.02.07.005--
Neuropathy peripheral17.09.03.003--Not Available
Oedema08.01.07.006; 14.05.06.010--Not Available
Orthostatic hypotension17.05.01.020; 24.06.03.004--Not Available
Osteoarthritis15.01.04.001--Not Available
Pain08.01.08.004--
Palpitations02.01.02.003--
Pharyngitis07.05.07.004; 11.01.13.003; 22.07.03.004--
Priapism21.03.01.005--Not Available
Pruritus23.03.12.001--
Pupillary disorder06.05.03.008; 17.02.11.006--Not Available
Rash23.03.13.001--Not Available
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