Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women.
Marketing Status Prescription; Discontinued
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bone pain15.02.01.0010.005153%
Bradycardia02.03.02.0020.001920%Not Available
Breast cancer16.10.01.001; 21.05.01.0030.004749%Not Available
Breast cyst16.14.01.004; 21.05.01.0060.000707%Not Available
Breast disorder female21.05.04.0070.000202%Not Available
Breast enlargement21.05.04.0010.000202%Not Available
Breast hyperplasia21.05.01.0070.000202%Not Available
Breast mass21.05.04.0020.002324%Not Available
Breast pain21.05.05.0030.000303%
Breath odour07.01.06.0020.000202%Not Available
Bronchiectasis22.03.02.0050.000202%Not Available
Bronchitis11.01.09.001; 22.07.01.0010.007174%
Bronchitis chronic22.03.01.0190.000808%Not Available
Bronchospasm10.01.03.012; 22.03.01.0040.000606%
Bruxism07.01.06.008; 19.11.03.0010.000808%Not Available
Bundle branch block left02.03.01.0070.002021%Not Available
Bundle branch block right02.03.01.0110.000808%Not Available
Burning sensation08.01.09.029; 17.02.06.001--Not Available
Bursitis15.04.01.0010.014953%Not Available
C-reactive protein increased13.09.01.007--Not Available
Cachexia08.01.01.009; 14.03.02.001; 16.32.03.0110.000053%Not Available
Calcinosis08.03.04.0020.000404%Not Available
Calcium deficiency05.04.02.004; 14.04.01.0130.004850%Not Available
Calculus urinary20.04.02.0010.000202%Not Available
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.001--
Cardiac failure congestive02.05.01.0020.005355%Not Available
Cardiac murmur13.14.01.0010.005961%Not Available
Cardio-respiratory arrest02.03.04.002; 22.02.06.007--Not Available
Cardiomegaly02.04.02.0010.000791%Not Available
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