Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Alendronate sodium
Drug ID BADD_D00065
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women.
Marketing Status Prescription; Discontinued
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D00939
MeSH ID D019386
PubChem ID 6331783
TTD Drug ID D09KLR
NDC Product Code 53104-7525; 50090-4692; 76282-682; 69543-130; 63629-7329; 50090-4076; 61919-689; 16714-633; 65862-329; 60429-055; 64980-340; 60723-205; 61919-729; 65862-268; 65862-328; 55111-874; 64980-342; 0115-1680; 69097-224; 60723-207; 65691-0056; 69097-223; 68071-1514; 50090-5677; 50090-2322; 0115-1678; 0115-1676; 70518-0033; 51224-301; 0054-0282; 78206-135; 71205-048; 0115-1679; 68788-7130; 50090-3593; 0115-1681; 50090-3126; 60429-056; 65862-327; 63415-0071; 16714-631; 68071-3171; 50090-5474; 65372-1134; 64980-341; 76282-681; 68071-3340; 68071-4017; 69543-131; 17139-400; 13371-111; 16714-632
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NNaO7P2
CAS Registry Number 129318-43-0
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN.[Na]
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Alopecia23.02.02.001--
Anastomotic ulcer haemorrhage07.04.04.004; 12.02.03.002; 24.07.02.001--Not Available
Angioedema10.01.05.009; 23.04.01.001--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Asthma10.01.03.010; 22.03.01.002--Not Available
Bone pain15.02.01.001--
Constipation07.02.02.001--
Diarrhoea07.02.01.001--
Disability26.01.01.003--Not Available
Dizziness02.01.02.004; 17.02.05.003; 24.06.02.007--
Duodenal ulcer07.04.02.002--
Dysgeusia07.14.03.001; 17.02.07.003--
Dyspepsia07.01.02.001--
Dysphagia07.01.06.003--
Episcleritis06.04.07.001; 10.02.01.024--Not Available
Erythema23.03.06.001--Not Available
Femur fracture12.04.01.003; 15.08.03.003--Not Available
Flatulence07.01.04.002--
Gastric ulcer07.04.03.002--
Gastritis07.08.02.001--
Gastrooesophageal reflux disease07.02.02.003--
Gastroduodenal ulcer07.04.02.005--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Headache17.14.01.001--
Hypocalcaemia14.04.01.004--
Joint swelling15.01.02.004--Not Available
Malaise08.01.01.003--
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