Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Senile dementia
ADR ID BADD_A07688
ADR Hierarchy
17      Nervous system disorders
17.03      Mental impairment disorders
17.03.01      Dementia (excl Alzheimer's type)
17.03.01.008      Senile dementia
19      Psychiatric disorders
19.20      Dementia and amnestic conditions
19.20.02      Dementia NEC
19.20.02.009      Senile dementia
Description A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57) [MeSH]
MedDRA Code 10039966
MeSH ID D000544
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Senile degeneration of brain with dementia | Senile dementia | Senile dementia NOS | Senile dementia with acute confusional state | Senile dementia with delirium | Senile dementia with delusional features | Senile dementia with delusional or depressive features | Senile dementia with depressive features | Senile dementia, depressed or paranoid type | Senile dementia, simple type | Senile dementia, uncomplicated | Senility | Senility without mention of psychosis | Alzheimer Disease | Alzheimer's Disease | Dementia, Senile | Senile Dementia | Dementia, Alzheimer Type | Alzheimer Type Dementia | Alzheimer-Type Dementia (ATD) | Alzheimer Type Dementia (ATD) | Dementia, Alzheimer-Type (ATD) | Alzheimer Type Senile Dementia | Primary Senile Degenerative Dementia | Dementia, Primary Senile Degenerative | Alzheimer Sclerosis | Sclerosis, Alzheimer | Alzheimer Syndrome | Alzheimer Dementia | Alzheimer Dementias | Dementia, Alzheimer | Dementias, Alzheimer | Senile Dementia, Alzheimer Type | Acute Confusional Senile Dementia | Senile Dementia, Acute Confusional | Dementia, Presenile | Presenile Dementia | Alzheimer Disease, Late Onset | Late Onset Alzheimer Disease | Alzheimer's Disease, Focal Onset | Focal Onset Alzheimer's Disease | Familial Alzheimer Disease (FAD) | Alzheimer Disease, Familial (FAD) | Alzheimer Diseases, Familial (FAD) | Familial Alzheimer Diseases (FAD) | Alzheimer Disease, Early Onset | Early Onset Alzheimer Disease | Presenile Alzheimer Dementia
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00151Apixaban0.000065%
BADD_D00405Ceftriaxone0.004457%
BADD_D01119Ibrutinib0.000112%
BADD_D01835Pregabalin0.000078%
BADD_D01955Rivastigmine0.000813%
BADD_D02058Sorafenib0.000112%
BADD_D02100Sunitinib0.000112%
BADD_D02331Valsartan0.000053%
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