Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Leukoencephalopathy
ADR ID BADD_A02520
ADR Hierarchy
17      Nervous system disorders
17.13      Encephalopathies
17.13.02      Encephalopathies NEC
17.13.02.003      Leukoencephalopathy
Description A disorder characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation. [CTCAE] Any of various diseases affecting the white matter of the central nervous system. [MeSH]
MedDRA Code 10024382
MeSH ID D056784
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Leukoencephalopathy | Disseminated necrotizing leukoencephalopathy | Disseminated necrotising leukoencephalopathy | Leukoencephalopathies | White Matter Diseases | Disease, White Matter | Diseases, White Matter | White Matter Disease | Childhood Ataxia with Central Nervous System Hypomyelinization | Leukoencephalopathy with Vanishing White Matter | Childhood Ataxia with Diffuse Central Nervous System Hypomyelination | Vanishing White Matter Leukodystrophy | Cree Leukoencephalopathy | Cree Leukoencephalopathies | Leukoencephalopathies, Cree | Leukoencephalopathy, Cree | Childhood Ataxia with Central Nervous System Hypomyelination | CACH Syndrome | CACH Syndromes | Syndrome, CACH | Syndromes, CACH | Myelinosis Centralis Diffusa | Centralis Diffusa, Myelinosis | Centralis Diffusas, Myelinosis | Diffusa, Myelinosis Centralis | Diffusas, Myelinosis Centralis | Myelinosis Centralis Diffusas | CACH VWM Syndrome | CACH VWM Syndromes | Syndrome, CACH VWM | Syndromes, CACH VWM | VWM Syndrome, CACH | VWM Syndromes, CACH
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00047Afatinib0.000168%
BADD_D00066Alendronic acid0.000044%
BADD_D00085Alprazolam0.000078%
BADD_D00193Axitinib0.000504%
BADD_D00194Azacitidine0.000168%
BADD_D00195Azathioprine0.000313%
BADD_D00230Bendamustine0.000112%
BADD_D00282Blinatumomab--
BADD_D00284Bortezomib0.000168%
BADD_D00330Cabozantinib0.000112%
BADD_D00349Capecitabine0.002015%
BADD_D00364Carboplatin0.000392%
BADD_D00474Cisplatin--
BADD_D00514Cocaine--
BADD_D00535Crizotinib0.000112%
BADD_D00551Cyclosporine0.001492%
BADD_D00560Cytarabine0.000112%
BADD_D00561Cytarabine hydrochloride--
BADD_D00623Dexamethasone0.000145%
BADD_D00643Diamminedichloroplatinum--
BADD_D00775Enzalutamide0.000334%
BADD_D00800Erlotinib0.000168%
BADD_D00879Fentanyl0.000529%
BADD_D00914Fludarabine0.000504%
BADD_D00931Fluorouracil0.002298%
BADD_D01130Idelalisib0.000112%
BADD_D01133Ifosfamide--
BADD_D01252Leflunomide0.000643%
BADD_D01254Lenvatinib0.000280%
BADD_D01265Levetiracetam0.000318%
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