Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tryptophan
Drug ID BADD_D02639
Description An essential amino acid that is necessary for normal growth in infants and for nitrogen balance in adults. It is a precursor of indole alkaloids in plants. It is a precursor of serotonin (hence its use as an antidepressant and sleep aid). It can be a precursor to niacin, albeit inefficiently, in mammals.
Indications and Usage Tryptophan may be useful in increasing serotonin production, promoting healthy sleep, managing depression by enhancing mental and emotional well-being, managing pain tolerance, and managing weight.
Marketing Status approved; nutraceutical; withdrawn
ATC Code N06AX02
DrugBank ID DB00150
KEGG ID D00020
MeSH ID D014364
PubChem ID 6305
TTD Drug ID D05EJG
NDC Product Code 43742-0770
UNII 8DUH1N11BX
Synonyms Tryptophan | L-Tryptophan | L Tryptophan | Levotryptophan | Ardeydorm | Ardeytropin | L-Tryptophan-ratiopharm | L Tryptophan ratiopharm | ratio-Tryptophan | ratio Tryptophan | Tryptophan Metabolism Alterations | PMS-Tryptophan | PMS Tryptophan | Trofan | Tryptacin | Tryptan | Optimax | Lyphan | Naturruhe
Chemical Information
Molecular Formula C11H12N2O2
CAS Registry Number 73-22-3
SMILES C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001---
Abdominal pain upper07.01.05.003--
Amnesia17.03.02.001; 19.20.01.001--
Angina pectoris02.02.02.002; 24.04.04.002--
Anxiety19.06.02.002--
Asthenia08.01.01.001---
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Condition aggravated08.01.03.004---
Confusional state17.02.03.005; 19.13.01.001--
Dependence19.07.06.008---
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Drug dependence19.07.06.011---
Dry mouth07.06.01.002--
Dysgeusia07.14.03.001; 17.02.07.003--
Eosinophilia01.02.04.001--
Eye pain06.08.03.002--
Feeling abnormal08.01.09.014---
Headache17.14.01.001--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Insomnia17.15.03.002; 19.02.01.002--
Irritability08.01.03.011; 19.04.02.013--
Memory impairment17.03.02.003; 19.20.01.003--
Myalgia15.05.02.001--
Mydriasis06.05.03.004; 17.02.11.003---
Nausea07.01.07.001--
Palpitations02.11.04.012--
Restlessness17.02.05.021; 19.11.02.002--
Serotonin syndrome12.03.01.041; 15.05.04.016; 17.05.02.004---
Skin warm23.03.03.014---
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