Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Phenylbutazone
Drug ID BADD_D02631
Description A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit considerations indicate that this drug should not be employed for this disease. (From AMA Drug Evaluations Annual, 1994, p1822)
Indications and Usage For the treatment of backache and ankylosing spondylitis
Marketing Status approved; vet_approved
ATC Code M01AA01; M02AA01
DrugBank ID DB00812
KEGG ID D00510
MeSH ID D010653
PubChem ID 4781
TTD Drug ID D07VHR
NDC Product Code 51552-1562; 59348-0010; 49452-5285; 60592-909; 51927-1011; 66064-1050
UNII GN5P7K3T8S
Synonyms Phenylbutazone | Diphenylbutazone | Butazolidin | Butadione | Butadion | Butacote | Butapyrazole | Butapirazol | Fenilbutazon
Chemical Information
Molecular Formula C19H20N2O2
CAS Registry Number 50-33-9
SMILES CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain upper07.01.05.003--
Agranulocytosis01.02.03.001---
Anaemia01.03.02.001--
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Aphthous ulcer07.05.06.002---
Aplastic anaemia01.03.03.002---
Cardiac failure congestive02.05.01.002---
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Cyanosis02.11.04.004; 22.02.02.007; 23.06.04.005; 24.03.01.007--
Dermatitis23.03.04.002---
Dermatitis bullous23.03.01.002--
Drug eruption08.01.06.015; 10.01.01.005; 23.03.05.001---
Dry mouth07.06.01.002--
Dyspepsia07.01.02.001--
Dyspnoea02.11.05.003; 22.02.01.004--
Erythema23.03.06.001---
Erythema multiforme10.01.03.015; 23.03.01.003--
Face oedema08.01.07.003; 10.01.05.002; 23.04.01.004--
Gastric haemorrhage07.12.01.001; 24.07.02.007--
Gastric ulcer07.04.03.002--
Gastritis07.08.02.001--
Gastrointestinal haemorrhage07.12.02.001; 24.07.02.009---
Generalised oedema08.01.07.004; 14.05.06.007--
Glossitis07.14.01.001---
Haematemesis07.12.02.002; 24.07.02.011---
Haematuria20.02.01.006; 21.10.01.018; 24.07.01.047--
Hepatitis09.01.07.004---
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Influenza like illness08.01.03.010--
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