| Pharmaceutical Information |
| Drug Name |
Astemizole |
| Drug ID |
BADD_D02613 |
| Description |
Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. |
| Indications and Usage |
Astemizole was indicated for use in the relieving allergy symptoms, particularly rhinitis and conjunctivitis. It has been withdrawn from the market however due to concerns of arrhythmias. |
| Marketing Status |
approved; withdrawn |
| ATC Code |
R06AX11 |
| DrugBank ID |
DB00637
|
| KEGG ID |
D00234
|
| MeSH ID |
D016589
|
| PubChem ID |
2247
|
| TTD Drug ID |
D0Y2HR
|
| NDC Product Code |
Not Available |
| UNII |
7HU6337315
|
| Synonyms |
Astemizole | Astemizol Alonga | Alonga, Astemizol | Astemizol Ratiopharm | Ratiopharm, Astemizol | Astesen | Emdar | Esmacen | Fustermizol | Hismanal | Histaminos | Hubermizol | Laridal | Paralergin | R-43-512 | R 43 512 | R43512 | Retolen | Rifedot | Rimbol | Romadin | Simprox | Urdrim | Alermizol | Astemina |
|
| Chemical Information |
| Molecular Formula |
C28H31FN4O |
| CAS Registry Number |
68844-77-9 |
| SMILES |
COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F |
| Chemical Structure |
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| ADRs Induced by Drug |
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