Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Calcium
Drug ID BADD_D02539
Description Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast.
Indications and Usage Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. It is vital in cell signaling, muscular contractions, bone health, and signalling cascades.
Marketing Status nutraceutical
ATC Code Not Available
DrugBank ID DB01373
KEGG ID Not Available
MeSH ID D002118
PubChem ID 5460341
TTD Drug ID D0PJ4K
NDC Product Code 55259-0002; 55259-0001; 55259-0007
UNII SY7Q814VUP
Synonyms Calcium | Blood Coagulation Factor IV | Coagulation Factor IV | Factor IV, Coagulation | Calcium-40 | Calcium 40 | Factor IV
Chemical Information
Molecular Formula Ca
CAS Registry Number 7440-70-2
SMILES [Ca]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Visual impairment06.02.10.0130.001840%-
Vomiting07.01.07.0030.001957%
Tubulointerstitial nephritis20.05.02.0020.000391%-
Hypoacusis04.02.01.0060.000783%
Peripheral swelling02.05.04.015; 08.01.03.0530.000979%-
Osteopenia14.04.04.004; 15.02.03.0030.000587%-
General physical health deterioration08.01.03.0180.001370%-
Balance disorder08.01.03.081; 17.02.02.0070.000587%-
Musculoskeletal chest pain15.03.04.012; 22.09.01.0010.000391%
Deep vein thrombosis24.01.02.0030.000979%-
Injection site discolouration08.02.03.038; 12.07.03.038; 23.03.03.0460.000861%-
Eyelids pruritus06.08.03.007; 23.03.12.0050.001996%-
Calciphylaxis14.04.01.0120.002740%-
Eye pruritus06.04.05.0060.001331%-
Injection site swelling08.02.03.017; 12.07.03.0180.000861%-
Bone metabolism disorder14.04.04.009; 15.02.03.0090.000391%-
Prostate cancer16.25.01.001; 21.04.02.0020.000587%-
Cardiac disorder02.11.01.0030.000783%-
Inflammation08.01.05.007; 10.02.01.0890.000391%-
Limb discomfort15.03.04.0140.000391%-
Lipid metabolism disorder14.08.04.0030.000391%-
Ischaemia24.04.02.0040.000861%-
Adverse drug reaction08.06.01.0090.000391%-
Renal impairment20.01.03.0100.000587%-
Osteonecrosis of jaw15.02.04.010; 24.04.05.0050.001174%
Chronic kidney disease20.01.03.0170.000391%
Pulmonary arterial hypertension22.06.01.002; 24.08.03.0030.000391%-
Bone loss15.02.04.0200.000391%-
Treatment failure08.06.01.0170.001057%-
Low birth weight baby18.04.02.0030.000783%-
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