Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dexmethylphenidate
Drug ID BADD_D02457
Description Dexmethylphenidate is the dextrorotary form of methylphenidate introduced in 2002[A177181]. It is a norepinephrine-dopamine reuptake inhibitor (NDRI) and thus a psychostimulant[A177193]. It is used for treatment of Attention Deficit Hyperactivity Disorder (ADHD)[Label,A177181]. The d-isomer is thought to have greater effect with fewer side effects than the l-isomer or the racemic mixture[A177181].
Indications and Usage Dexmethylphenidate is used as a treatment for ADHD, ideally in conjunction with psychological, educational, behavioral or other forms of treatment[A177187,Label].
Marketing Status approved; investigational
ATC Code N06BA11
DrugBank ID DB06701
KEGG ID D07806
MeSH ID D064699
PubChem ID 154101
TTD Drug ID D02QCD
NDC Product Code Not Available
UNII M32RH9MFGP
Synonyms Dexmethylphenidate Hydrochloride | Hydrochloride, Dexmethylphenidate | Focalin XR | XR, Focalin | Dexmethylphenidate | Focalin
Chemical Information
Molecular Formula C14H19NO2
CAS Registry Number 40431-64-9
SMILES COC(=O)C(C1CCCCN1)C2=CC=CC=C2
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Therapeutic response unexpected08.06.01.0010.000869%-
Thinking abnormal17.02.05.023; 19.10.03.0010.000256%-
Tic17.02.05.024; 19.11.04.0010.001585%-
Tremor17.01.06.0020.001295%
Ventricular fibrillation02.03.04.0080.000170%
Vision blurred06.02.06.007; 17.17.01.0100.000869%
Visual impairment06.02.10.0130.000750%-
Energy increased08.01.03.0170.001449%-
Performance status decreased08.01.03.0420.001534%-
Eye movement disorder06.05.02.008; 17.02.05.0250.000375%-
Abnormal behaviour19.01.01.0010.007756%-
Decreased appetite08.01.09.028; 14.03.01.0050.005761%
Adverse drug reaction08.06.01.0090.000869%-
Drug intolerance08.06.01.0130.001244%-
Grimacing17.02.05.0290.000170%-
Unevaluable event08.01.03.0510.000375%-
Autism spectrum disorder17.03.05.003; 19.22.02.0020.000511%-
Treatment failure08.06.01.0170.000665%-
Communication disorder19.19.01.0080.000170%-
Attention deficit hyperactivity disorder19.21.04.0040.001705%-
Behaviour disorder19.01.01.0050.000580%-
Therapeutic product effect decreased08.06.01.0500.001415%-
Therapeutic product effect incomplete08.06.01.0520.000375%-
Therapeutic response changed08.06.01.0590.000375%-
Therapy non-responder08.06.01.0630.001449%-
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