Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Loperamide
Drug ID BADD_D02428
Description One of the long-acting synthetic antidiarrheals; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
Indications and Usage For the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease or gastroenteritis. Also used for reducing the volume of discharge from ileostomies.
Marketing Status approved
ATC Code A07DA03
DrugBank ID DB00836
KEGG ID D08144
MeSH ID D008139
PubChem ID 3955
TTD Drug ID D0CS2F
NDC Product Code Not Available
UNII 6X9OC3H4II
Synonyms Loperamide | R-18553 | R 18553 | R18553 | Imodium | Loperamide Hydrochloride | Hydrochloride, Loperamide | Loperamide Monohydrochloride | Monohydrochloride, Loperamide
Chemical Information
Molecular Formula C29H33ClN2O2
CAS Registry Number 53179-11-6
SMILES CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Brain oedema12.01.10.010; 17.07.02.0030.000676%
General physical health deterioration08.01.03.018---
Ventricular hypokinesia02.04.02.0130.000338%-
Haemodynamic instability24.03.02.0060.000507%-
Musculoskeletal stiffness15.03.05.027---
Haemorrhage24.07.01.002---
Faecaloma07.01.03.0040.000338%-
Colitis microscopic07.08.01.011---
Pulseless electrical activity02.03.04.0200.000338%-
Hot flush08.01.03.027; 21.02.02.001; 24.03.01.005--
Adverse event08.06.01.0100.000913%-
Cardiac disorder02.11.01.0030.000338%-
Gastrointestinal motility disorder07.02.03.001---
Therapeutic reaction time decreased08.06.01.015---
Decreased appetite08.01.09.028; 14.03.01.005--
Cytopenia01.03.03.0120.000507%-
Sphincter of Oddi dysfunction07.18.02.002; 09.02.02.0040.000338%-
Treatment failure08.06.01.017---
Brain injury17.11.01.003; 19.07.03.0070.000507%-
Anorectal discomfort07.03.03.003---
Oropharyngeal pain07.05.05.004; 22.12.03.016--
Acute kidney injury20.01.03.0160.000845%
Faeces soft07.01.03.008---
Anal incontinence07.01.06.029; 17.05.01.021--
Stress cardiomyopathy02.04.01.012; 24.04.04.0260.000676%-
Seizure like phenomena17.12.03.0300.000338%-
Arrhythmic storm02.03.04.0210.000507%-
Dilated cardiomyopathy02.04.01.0170.000676%-
Drug use disorder19.07.06.0120.001690%-
Illness08.01.03.091---
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