| Pharmaceutical Information |
| Drug Name |
Vinflunine |
| Drug ID |
BADD_D02362 |
| Description |
Vinflunine is a third-generation member of the vinca alkaloid family with anti-tumour actions. It was first described in 1998 at the Pierre Fabre research center in France. Like other vinca agents, vinflunine is an anti-mitotic agent that induces a cell cycle arrest at the G2/M phase and promotes cell death via apoptosis [L1396]. Vinflunine is a microtubule inhibitor that binds to tubulin at or near to the vinca binding sites to inhibits its polymerization into microtubules during cell proliferation [L1396]. In murine tumors and human tumor xenografts, vinflunine exhibits an antitumor efficacy than [DB00361], [DB00570], and [DB00541] [A31975].
Having an incidence of 429,700 new cases per year worldwide, urothelial carcinoma of the bladder is one of the most common malignancies that mostly affects individuals aged 50–79 years [A32626]. Some patients with advanced urothelial carcinoma experience inadequate therapeutic response from a prior platinum-containing regimen. While these patients have a median survival of approximately 4 months and a poor prognosis [L1396], there is currently no standard therapy in patients with advanced urothelial carcinoma [A32626]. In 2009, vinflunine was approved by the European Medicines Agency (EMA) as a second-line therapy of metastatic and advanced urothelial cancer after failure of platinum-based treatment [A32626]. Vinflunine ditartrate is an active ingredient in the EMA-authorised product Javlor for intravenous infusion. Efficacy and safety of vinflunine has not been studied in patients with performance status of 2 or less. The clinical use of vinflunine in other urologic malignancies, such as inoperable cancer of the penis, are currently have been investigated [A32626]. |
| Indications and Usage |
For use as a monotherapy in adults with advanced or transitional cell carcinoma of the urothelial tract after failure of a prior platinum-containing therapy [L2381]. |
| Marketing Status |
approved; investigational |
| ATC Code |
L01CA05 |
| DrugBank ID |
DB11641
|
| KEGG ID |
D09032
|
| MeSH ID |
C111217
|
| PubChem ID |
10629256
|
| TTD Drug ID |
D0OT9S
|
| NDC Product Code |
Not Available |
| UNII |
5BF646324K
|
| Synonyms |
vinflunine | Javlor |
|
| Chemical Information |
| Molecular Formula |
C45H54F2N4O8 |
| CAS Registry Number |
162652-95-1 |
| SMILES |
CCC12C=CCN3C1C4(CC3)C(C(C2OC(=O)C)(C(=O)OC)O)N(C5=CC(=C(C=C45)C6(CC7CC(CN(C7)CC8
=C6NC9=CC=CC=C89)C(C)(F)F)C(=O)OC)OC)C |
| Chemical Structure |
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| ADRs Induced by Drug |
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