Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Vinblastine sulfate
Drug ID BADD_D02359
Description Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
Indications and Usage For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.
Marketing Status approved
ATC Code L01CA01
DrugBank ID DB00570
KEGG ID D01068
MeSH ID D014747
PubChem ID 5388983
TTD Drug ID D0W9MM
NDC Product Code 53104-7504; 63323-278; 48954-588
UNII N00W22YO2B
Synonyms Vinblastine | Vincaleukoblastine | Lemblastine | Velban | Vinblastina Lilly | Velbe | Vinblastine Sulfate | Sulfate, Vinblastine | Vinblastinsulfat-Gry | Cellblastin | Vinblastin Hexal
Chemical Information
Molecular Formula C46H58N4O9.H2O4S
CAS Registry Number 143-67-9
SMILES CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8 N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Agranulocytosis01.02.03.001---
Alopecia23.02.02.001--
Anaemia01.03.02.001--
Angina pectoris02.02.02.002; 24.04.04.002--
Asthenia08.01.01.001---
Bone pain15.02.01.001--
Cellulitis11.02.01.001; 23.11.02.004---
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Constipation07.02.02.001--
Deafness04.02.01.001---
Depilation25.12.01.002---
Depression19.15.01.001--
Diarrhoea07.02.01.001--
Discomfort08.01.08.003---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Electrocardiogram abnormal13.14.05.001---
Enterocolitis haemorrhagic07.08.01.007; 24.07.02.006---
Extravasation08.01.03.008---
Feeling abnormal08.01.09.014---
Gastrointestinal pain07.01.05.005--
Haemoglobin13.01.05.018---
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023; 23.03.03.081---
Hyporeflexia17.02.01.003--
Ileus07.13.01.001--
Ileus paralytic07.02.05.001---
Leukopenia01.02.02.001---
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