Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Trospium
Drug ID BADD_D02305
Description Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably.[L6208] An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination.[L6208] Trospium is manufactured by _Indevus Pharmaceutical Inc._ and was granted FDA approval in 2007.[L6211]
Indications and Usage For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency, detrusor instability and frequency of micturition.
Marketing Status approved
ATC Code G04BD09
DrugBank ID DB00209
KEGG ID D01103
MeSH ID C003330
PubChem ID 5284632
TTD Drug ID D05TIB
NDC Product Code Not Available
UNII T4Y8ORK057
Synonyms trospium chloride | azoniaspiro compound XVII | azoniaspiro(3 alpha-benziloyloxynortropane-8,1'- pyrrolidine) chloride | Spasmex | Uraton | Spasmolyt | Spasmo-Urgenin TC | Spasmo-lyt | Spasmo-Rhoival TC | Trospi | Ceris | Uraplex | Spasmo-Urgenin
Chemical Information
Molecular Formula C25H30NO3+
CAS Registry Number 47608-32-2
SMILES C1CC[N+]2(C1)C3CCC2CC(C3)OC(=O)C(C4=CC=CC=C4)(C5=CC=CC=C5)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001---
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Accommodation disorder06.02.04.001---
Anaphylactic shock10.01.07.002; 24.06.02.004---
Angina pectoris02.02.02.002; 24.04.04.002--
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Asthenia08.01.01.001---
Back pain15.03.04.005--
Bladder pain20.02.02.001---
Blood uric acid increased13.02.04.001---
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Confusional state17.02.03.005; 19.13.01.001--
Constipation07.02.02.001--
Coronary artery disease02.02.01.001; 24.04.04.006---
Delirium19.13.02.001--
Dermatitis23.03.04.002---
Dermatitis contact10.01.01.003; 12.03.01.040; 23.03.04.004---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dry eye06.08.02.001--
Dry mouth07.06.01.002--
Dry skin23.03.03.001--
Dry throat07.06.01.005; 22.12.03.005---
Dysgeusia07.14.03.001; 17.02.07.003--
Dyspepsia07.01.02.001--
Dysphonia17.02.08.004; 19.19.03.002; 22.12.03.006--
Dysuria20.02.02.002--
Ear disorder04.03.01.001---
Ear pain04.03.01.003--
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