Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Triprolidine hydrochloride
Drug ID BADD_D02296
Description First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness.
Indications and Usage For the symptomatic relief of seasonal or perennial allergic rhinitis or nonallergic rhinitis; allergic conjunctivitis; and mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Also used in combination with other agents for the symptomatic relief of symptoms associated with the common cold.
Marketing Status approved
ATC Code R06AX07
DrugBank ID DB00427
KEGG ID D01782
MeSH ID D014311
PubChem ID 5702129
TTD Drug ID D0E8CI
NDC Product Code 58809-651; 70868-730; 66651-906; 70154-204; 69367-253; 28595-808; 0536-1257; 62331-046; 28595-801; 28595-802; 57218-900; 71321-701
UNII YAN7R5L890
Synonyms Triprolidine | Triprolidine Hydrochloride | Hydrochloride, Triprolidine | Triprolidine Monohydrochloride | Triprolidine Monohydrochloride, Monohydrate | Pro Actidil | Triprolidine Hydrochloride Anhydrous | Anhydrous, Triprolidine Hydrochloride | Hydrochloride Anhydrous, Triprolidine | Triprolidine Oxalate | Triprolidine Oxalate, (trans)-Isomer | Triprolidine, (Z)-Isomer | Actidil | Triprolidine Monohydrochloride, (Z)-Isomer
Chemical Information
Molecular Formula C19H23ClN2
CAS Registry Number 6138-79-0
SMILES CC1=CC=C(C=C1)C(=CCN2CCCC2)C3=CC=CC=N3.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dermatitis23.03.04.002---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dry mouth07.06.01.002--
Dyspepsia07.01.02.001--
Dysuria20.02.02.002--
Headache17.14.01.001--
Nausea07.01.07.001--
Nervousness19.06.02.003---
Polyuria20.02.03.002---
Somnolence17.02.04.006; 19.02.05.003--
Urinary retention20.02.02.011--
Vision blurred06.02.06.007; 17.17.01.010--
Vomiting07.01.07.003--
Decreased appetite08.01.09.028; 14.03.01.005--
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