Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Trimethadione
Drug ID BADD_D02287
Description An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
Indications and Usage Used in the control of absence (petit mal) seizures that are refractory to treatment with other medications.
Marketing Status Prescription; Discontinued
ATC Code N03AC02
DrugBank ID DB00347
KEGG ID D00392
MeSH ID D014293
PubChem ID 5576
TTD Drug ID D0U4VT
NDC Product Code 43798-500
Synonyms Trimethadione | Troxidone | Tridione | Trimetin
Chemical Information
Molecular Formula C6H9NO3
CAS Registry Number 127-48-0
SMILES CC1(C(=O)N(C(=O)O1)C)C
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Agranulocytosis01.02.03.001--Not Available
Albuminuria20.02.01.001--Not Available
Alopecia23.02.02.001--
Aplastic anaemia01.03.03.002--Not Available
Asthenia08.01.01.001--Not Available
Blindness06.02.02.001; 17.17.01.003--Not Available
Blindness day06.02.02.007--Not Available
Blood pressure abnormal13.14.03.001--Not Available
Blood pressure fluctuation24.06.01.002--Not Available
Dermatitis23.03.04.002--Not Available
Dermatitis exfoliative10.01.01.004; 23.03.07.001--
Diplopia06.02.06.002; 17.17.01.005--Not Available
Discomfort08.01.08.003--Not Available
Dyspepsia07.01.02.001--
Eosinophilia01.02.04.001--
Epistaxis22.04.03.001; 24.07.01.005--
Erythema multiforme10.01.03.015; 23.03.01.003--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Gastrointestinal pain07.01.05.005--
Generalised tonic-clonic seizure17.12.01.002--Not Available
Gingival bleeding07.09.07.001; 24.07.02.010--Not Available
Haemoglobin13.01.05.018--Not Available
Headache17.14.01.001--
Hepatitis09.01.07.004--Not Available
Hepatosplenomegaly01.09.03.001; 09.01.05.002--Not Available
Hiccups07.01.06.009; 22.02.04.002--
Hypoplastic anaemia01.03.03.006--Not Available
Insomnia17.15.03.002; 19.02.01.002--
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