| Drug Name |
Tretinoin |
| Drug ID |
BADD_D02270 |
| Description |
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL). |
| Indications and Usage |
For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.
Tretinoin is also indicated in combination with [benzoyl peroxide] for the treatment of acne vulgaris in patients aged nine years and older.[L34869] |
| Marketing Status |
approved; investigational; nutraceutical |
| ATC Code |
D10AD01; L01XF01 |
| DrugBank ID |
DB00755
|
| KEGG ID |
D00094
|
| MeSH ID |
D014212
|
| PubChem ID |
444795
|
| TTD Drug ID |
D02DGU
|
| NDC Product Code |
17337-0036; 17337-0045; 42291-870; 0187-5160; 51672-1395; 70518-3223; 0904-6867; 76055-0007; 79572-030; 0187-0005; 51672-1407; 62032-413; 0378-8083; 0378-8090; 0378-8093; 68462-792; 76420-159; 0187-5150; 0187-5172; 53002-8101; 0378-6141; 68084-075; 68682-513; 68682-514; 0555-0808; 0574-2201; 0574-2225; 62032-414; 63629-9123; 63629-9124; 0378-8086; 0574-2205; 55361-0029; 62049-003; 16714-249; 62032-417; 0378-8082; 0378-8084; 49452-6243; 55361-0028; 0187-5140; 0187-5148; 0187-5164; 0187-5170; 51672-1394; 63629-2285; 68682-800; 0574-2301; 51552-0120; 10370-268; 64566-0009; 71052-401; 0187-5146; 0378-8085; 0378-8092; 68634-069; 50090-0651; 0472-0117; 70518-3233; 51927-1270; 62032-412; 68071-2674; 0574-2325; 62991-2057; 0187-5144; 50090-4347; 63629-8752; 38779-0001; 48943-0011; 13548-070; 16714-250; 0187-5162 |
| UNII |
5688UTC01R
|
| Synonyms |
Tretinoin | Retinoic Acid | Acid, Retinoic | Vitamin A Acid | Acid, Vitamin A | all-trans-Retinoic Acid | Acid, all-trans-Retinoic | all trans Retinoic Acid | trans-Retinoic Acid | Acid, trans-Retinoic | trans Retinoic Acid | Retin-A | Retin A | Tretinoin Potassium Salt | Potassium Salt, Tretinoin | Salt, Tretinoin Potassium | Tretinoin Zinc Salt | Salt, Tretinoin Zinc | Zinc Salt, Tretinoin | Vesanoid | beta-all-trans-Retinoic Acid | Acid, beta-all-trans-Retinoic | beta all trans Retinoic Acid | Tretinoin Sodium Salt | Salt, Tretinoin Sodium | Sodium Salt, Tretinoin |
