Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Treprostinil
Drug ID BADD_D02268
Description Treprostinil is a synthetic analogue of prostacyclin, used to treat pulmonary hypertension.
Indications and Usage For use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise.
Marketing Status approved; investigational
ATC Code B01AC21
DrugBank ID DB00374
KEGG ID D06213
MeSH ID C427248
PubChem ID 6918140
TTD Drug ID D01WUA
NDC Product Code 0703-0696; 0781-3430; 11014-0094; 66302-350; 66302-648; 66302-748; 66302-361; 66302-363; 66302-620; 66302-720; 0703-0676; 43598-646; 43598-647; 66302-302; 66302-325; 66302-616; 66302-362; 0703-0666; 14501-0015; 42023-209; 62332-515; 66302-110; 66302-300; 66302-610; 54893-0024; 43598-649; 62332-514; 62332-517; 66302-102; 66302-206; 66302-732; 58159-041; 68245-0008; 43598-648; 66302-120; 66302-600; 66302-650; 66302-764; 0703-0686; 0781-3420; 0781-3425; 81861-0029; 66302-101; 66302-310; 66302-630; 66302-664; 0781-3427; 42023-206; 66302-105; 66302-640; 42023-207; 62332-516; 66302-632; 66302-716; 42023-208
UNII RUM6K67ESG
Synonyms treprostinil | ((1R,2R,3AS,9AS)-2-hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3A,4,9,9A-hexahydro-1H-cylopent(b)naphthalen-5-yl)oxy)acetate | treprostinil sodium | trepostinil sodium | Orenitram | UT-15 | UT-15C | Remodulin | treprostinil diolamine | treprostinil diolamin | treprostinil diethanolamine
Chemical Information
Molecular Formula C23H34O5
CAS Registry Number 81846-19-7
SMILES CCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)O)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Fatigue08.01.01.0020.022042%
Feeling abnormal08.01.09.0140.007978%-
Feeling cold08.01.09.0080.001143%-
Flank pain08.01.08.007; 15.03.04.003; 20.02.03.0060.000724%
Flatulence07.01.04.0020.001258%
Fluid retention14.05.06.002; 20.01.02.0030.009886%-
Flushing08.01.03.025; 23.06.05.003; 24.03.01.0020.011967%
Food allergy10.01.01.0120.000181%-
Frequent bowel movements07.02.04.0020.000600%-
Gait disturbance08.01.02.002; 15.03.05.013; 17.02.05.016--
Gallbladder disorder09.03.02.0010.000345%-
Gastric ulcer haemorrhage07.04.03.005; 24.07.02.0030.000082%-
Gastritis07.08.02.0010.000444%
Gastrointestinal disorder07.11.01.0010.004515%-
Gastrointestinal haemorrhage07.12.02.001; 24.07.02.0090.002097%-
Gastrointestinal pain07.01.05.0050.000181%
Generalised oedema08.01.07.004; 14.05.06.0070.000551%
Gingival pain07.09.13.0100.000419%
Gingival swelling07.09.13.0130.000181%-
Glossodynia07.14.02.0010.000419%-
Gout14.09.01.001; 15.01.06.0010.001143%-
Haematemesis07.12.02.002; 24.07.02.011---
Haematochezia07.12.02.003; 24.07.02.0120.000452%-
Haematoma24.07.01.001--
Haematuria20.02.01.006; 21.10.01.018; 24.07.01.047--
Haemoglobin13.01.05.018---
Haemoptysis02.11.04.009; 22.02.03.004; 24.07.01.0060.002278%-
Head discomfort17.02.05.0270.000600%-
Headache17.14.01.0010.057218%
Hepatic cirrhosis09.01.04.0010.000247%-
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ADReCS-Target
Drug Name ADR Term Target
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