ADReCS

Pharmaceutical Information

Drug Name	Treprostinil
Drug ID	BADD_D02268
Description	Treprostinil is a synthetic analogue of prostacyclin, used to treat pulmonary hypertension.
Indications and Usage	For use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise.
Marketing Status	approved; investigational
ATC Code	B01AC21
DrugBank ID	DB00374
KEGG ID	D06213
MeSH ID	C427248
PubChem ID	6918140
TTD Drug ID	D01WUA
NDC Product Code	0703-0696; 0781-3430; 11014-0094; 66302-350; 66302-648; 66302-748; 66302-361; 66302-363; 66302-620; 66302-720; 0703-0676; 43598-646; 43598-647; 66302-302; 66302-325; 66302-616; 66302-362; 0703-0666; 14501-0015; 42023-209; 62332-515; 66302-110; 66302-300; 66302-610; 54893-0024; 43598-649; 62332-514; 62332-517; 66302-102; 66302-206; 66302-732; 58159-041; 68245-0008; 43598-648; 66302-120; 66302-600; 66302-650; 66302-764; 0703-0686; 0781-3420; 0781-3425; 81861-0029; 66302-101; 66302-310; 66302-630; 66302-664; 0781-3427; 42023-206; 66302-105; 66302-640; 42023-207; 62332-516; 66302-632; 66302-716; 42023-208
UNII	RUM6K67ESG
Synonyms	treprostinil \| ((1R,2R,3AS,9AS)-2-hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3A,4,9,9A-hexahydro-1H-cylopent(b)naphthalen-5-yl)oxy)acetate \| treprostinil sodium \| trepostinil sodium \| Orenitram \| UT-15 \| UT-15C \| Remodulin \| treprostinil diolamine \| treprostinil diolamin \| treprostinil diethanolamine

Chemical Information

Molecular Formula	C23H34O5
CAS Registry Number	81846-19-7
SMILES	CCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)O)O)O
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Cardiac dysfunction	02.11.01.004	0.000181%		-
Catheter site discharge	08.02.02.016; 12.07.02.016	0.000304%		-
Combined pulmonary fibrosis and emphysema	22.01.02.028	0.000082%		-
Device allergy	08.07.01.014; 10.01.03.054	0.000280%		-
Disease complication	08.01.03.087	0.000123%		-
Haemorrhagic cholecystitis	09.03.01.008; 24.07.01.094	0.000164%		-
Hyperaesthesia teeth	07.09.06.005	0.000280%		-
Illness	08.01.03.091	0.001069%		-
Implant site erythema	08.02.02.040; 12.07.02.040; 23.03.06.024	0.000082%		-
Implant site extravasation	08.02.02.042; 12.07.02.042	0.000164%		-
Implant site swelling	08.02.02.063; 12.07.02.063	0.000082%		-
Infusion site bruising	08.02.05.022; 12.07.05.022; 23.03.11.034; 24.07.06.030	0.000461%		-
Infusion site discharge	08.02.05.025; 12.07.05.025	0.003043%		-
Infusion site discolouration	08.02.05.026; 12.07.05.026; 23.03.03.084	0.000962%		-
Infusion site discomfort	08.02.05.027; 12.07.05.027	0.001003%		-
Infusion site erosion	08.02.05.028; 12.07.05.028; 23.07.03.027	0.000321%		-
Infusion site injury	08.02.05.031; 12.07.05.031	0.000280%		-
Infusion site mass	08.02.05.032; 12.07.05.032	-	-	-
Infusion site nodule	08.02.05.034; 12.07.05.034; 23.07.04.042	0.000642%		-
Infusion site scab	08.02.05.035; 12.07.05.035; 23.03.03.085	0.000419%		-
Infusion site scar	08.02.05.036; 12.07.05.036; 23.03.11.035	0.000543%		-
Infusion site streaking	08.02.05.037; 12.07.05.037	0.000280%		-
Infusion site vesicles	08.02.05.038; 12.07.05.038; 23.03.01.036	0.000502%		-
Injection site discharge	08.02.03.057; 12.07.03.057	0.001711%		-
Injection site erosion	08.02.03.058; 12.07.03.058; 23.07.03.028	0.000280%		-
Injection site scab	08.02.03.069; 12.07.03.069; 23.03.03.088	0.000181%		-
Lung transplant rejection	10.02.03.011; 12.02.07.015; 22.01.01.029	0.000082%		-
Malabsorption from injection site	08.02.03.071; 12.07.03.071	0.000222%		-
Sinus pain	22.12.03.023	0.000280%
Sleep deficit	17.15.04.010	0.000280%		-

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