Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Treprostinil
Drug ID BADD_D02268
Description Treprostinil is a synthetic analogue of prostacyclin, used to treat pulmonary hypertension.
Indications and Usage For use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise.
Marketing Status approved; investigational
ATC Code B01AC21
DrugBank ID DB00374
KEGG ID D06213
MeSH ID C427248
PubChem ID 6918140
TTD Drug ID D01WUA
NDC Product Code 0703-0696; 0781-3430; 11014-0094; 66302-350; 66302-648; 66302-748; 66302-361; 66302-363; 66302-620; 66302-720; 0703-0676; 43598-646; 43598-647; 66302-302; 66302-325; 66302-616; 66302-362; 0703-0666; 14501-0015; 42023-209; 62332-515; 66302-110; 66302-300; 66302-610; 54893-0024; 43598-649; 62332-514; 62332-517; 66302-102; 66302-206; 66302-732; 58159-041; 68245-0008; 43598-648; 66302-120; 66302-600; 66302-650; 66302-764; 0703-0686; 0781-3420; 0781-3425; 81861-0029; 66302-101; 66302-310; 66302-630; 66302-664; 0781-3427; 42023-206; 66302-105; 66302-640; 42023-207; 62332-516; 66302-632; 66302-716; 42023-208
UNII RUM6K67ESG
Synonyms treprostinil | ((1R,2R,3AS,9AS)-2-hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3A,4,9,9A-hexahydro-1H-cylopent(b)naphthalen-5-yl)oxy)acetate | treprostinil sodium | trepostinil sodium | Orenitram | UT-15 | UT-15C | Remodulin | treprostinil diolamine | treprostinil diolamin | treprostinil diethanolamine
Chemical Information
Molecular Formula C23H34O5
CAS Registry Number 81846-19-7
SMILES CCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)O)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Catheter site pain08.02.02.004; 12.07.02.0040.000724%-
Paranasal sinus discomfort22.12.03.0180.000419%-
Drug tolerance decreased08.06.01.0240.000321%-
Musculoskeletal discomfort15.03.04.0010.000362%-
Injection site swelling08.02.03.017; 12.07.03.0180.000625%-
Secretion discharge08.01.03.0190.000362%-
Infusion site induration08.02.05.009; 12.07.05.0100.001727%-
Infusion site pain08.02.05.014; 12.07.05.0020.016959%-
Infusion site warmth08.02.05.011; 12.07.05.0120.001727%-
Infusion site swelling08.02.05.002; 12.07.05.0030.005601%-
Infusion site pruritus08.02.05.004; 12.07.05.005; 23.03.12.0060.002262%-
Infusion site oedema08.02.05.012; 12.07.05.0130.000567%-
Skin burning sensation17.02.06.009; 23.03.03.0210.000461%-
Infusion site reaction08.02.05.005; 12.07.05.0060.001012%-
Infusion site infection08.02.05.019; 11.01.15.003; 12.07.05.019---
Haemorrhage24.07.01.002---
Infusion site inflammation08.02.05.020; 12.07.05.0200.000724%-
Pulmonary mass22.02.07.0040.000222%-
Pharyngeal erythema22.04.05.0100.000280%-
Temperature intolerance08.01.09.0220.000321%-
Hypoaesthesia oral07.05.05.003; 17.02.06.0210.000543%-
Paranasal sinus hypersecretion22.04.06.0040.000600%-
Pulseless electrical activity02.03.04.0200.000164%-
Pseudomonal sepsis11.02.12.003---
Restless legs syndrome15.05.03.012; 17.02.07.0080.000740%-
Haemobilia09.01.08.009; 24.07.01.0490.000082%-
Ventricular dysfunction02.04.02.0050.000181%-
Infusion site rash08.02.05.017; 12.07.05.017; 23.03.13.0180.001061%-
Induration08.01.03.020---
Limb discomfort15.03.04.0140.001382%-
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ADReCS-Target
Drug Name ADR Term Target
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