Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Torsemide
Drug ID BADD_D02251
Description Torasemide is a high-ceiling loop diuretic.[A174463] Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent.[A319] Torasemide was first approved for clinical use by the FDA in 1993.[L5257]
Indications and Usage Torasemide is indicated for the treatment of edema associated with congestive heart failure, renal or hepatic diseases. From this condition, it has been observed that torasemide is very effective in cases of kidney failure.[FDA label] As well, torasemide is approved to be used as an antihypertensive agent either alone or in combination with other antihypertensives.[FDA label]
Marketing Status approved
ATC Code C03CA04
DrugBank ID DB00214
KEGG ID D00382
MeSH ID D000077786
PubChem ID 41781
TTD Drug ID D0J9XZ
NDC Product Code 73502-288; 51604-0020; 65862-127; 72166-010; 23155-874; 31722-532; 42291-819; 73502-687; 65862-128; 31722-531; 42291-816; 42291-817; 42291-818; 50090-6499; 50111-916; 50111-917; 51407-362; 65862-126; 31722-530; 43353-315; 57237-141; 57237-138; 0054-0077; 70518-2744; 73502-286; 51604-0018; 64220-125; 23155-873; 50268-757; 0615-7997; 23155-871; 50111-915; 50268-755; 50268-756; 57237-139; 65862-125; 65862-539; 68554-0025; 23155-872; 31722-529; 63629-1346; 73502-586; 71335-2143; 57451-1189; 50090-6495; 67296-1471; 0904-7283; 66064-1012; 68084-539; 72189-102; 73502-287; 73502-786; 69037-0054; 50111-918; 50268-754; 57237-140
UNII W31X2H97FB
Synonyms Torsemide | Torasemide | 1-Isopropyl-3-((4-m-toluidino-3-pyridyl)sulfonyl)urea | 1-Isopropyl-3-((4-(3-methylphenylamino)pyridine)-3-sulfonyl)urea | Demadex
Chemical Information
Molecular Formula C16H20N4O3S
CAS Registry Number 56211-40-6
SMILES CC1=CC(=CC=C1)NC2=C(C=NC=C2)S(=O)(=O)NC(=O)NC(C)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Alkalosis hypochloraemic14.01.02.003---
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Asthenia08.01.01.0010.000614%-
Atrial fibrillation02.03.03.002--
Blood uric acid increased13.02.04.001---
Bradycardia02.03.02.0020.000569%-
Cardiac failure02.05.01.0010.000341%
Cardiac failure congestive02.05.01.0020.001138%-
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Completed suicide08.04.01.010; 19.12.01.0010.000455%-
Condition aggravated08.01.03.0040.000341%-
Confusional state17.02.03.005; 19.13.01.0010.000228%
Constipation07.02.02.0010.000455%
Cough22.02.03.001--
Dehydration14.05.05.0010.000569%
Dermatitis23.03.04.002---
Diarrhoea07.02.01.001--
Disorientation17.02.05.015; 19.13.01.0020.000341%-
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.0070.000341%
Drug ineffective08.06.01.0060.001570%-
Dyspepsia07.01.02.001--
Dyspnoea02.11.05.003; 22.02.01.0040.000614%
Electrocardiogram abnormal13.14.05.001---
Electrolyte imbalance14.05.01.0020.000228%-
Erythema multiforme10.01.03.015; 23.03.01.003--
Fatigue08.01.01.0020.001001%
Fluid retention14.05.06.002; 20.01.02.0030.000228%-
Gastrointestinal haemorrhage07.12.02.001; 24.07.02.009---
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