Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tolazoline hydrochloride
Drug ID BADD_D02239
Description A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn.
Indications and Usage For the treatment of pulmonary artery anomalies
Marketing Status approved; vet_approved
ATC Code M02AX02; C04AB02
DrugBank ID DB00797
KEGG ID D00997
MeSH ID D014043
PubChem ID 6048
TTD Drug ID D03RZV
NDC Product Code Not Available
UNII E669Z6S1JG
Synonyms Tolazoline | Benzalolin | Priscoline | Priscol | Tolazoline Hydrochloride | Tolazoline Monohydrochloride | Divascol | Pridazole
Chemical Information
Molecular Formula C10H13ClN2
CAS Registry Number 59-97-2
SMILES C1CN=C(N1)CC2=CC=CC=C2.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Arrhythmia02.03.02.001---
Diarrhoea07.02.01.001--
Feeling cold08.01.09.008---
Flushing08.01.03.025; 23.06.05.003; 24.03.01.002--
Gastrointestinal haemorrhage07.12.02.001; 24.07.02.009---
Haematuria20.02.01.006; 21.10.01.018; 24.07.01.047--
Hepatitis09.01.07.004---
Hypertension24.08.02.001--
Hypotension24.06.03.002--
Leukopenia01.02.02.001---
Nausea07.01.07.001--
Oedema08.01.07.006; 14.05.06.010---
Oliguria20.01.03.004---
Paraesthesia17.02.06.005; 23.03.03.094--
Pulmonary haemorrhage22.12.01.009; 24.07.01.016--
Rash23.03.13.001---
Tachycardia02.03.02.007---
Thrombocytopenia01.08.01.002---
Vomiting07.01.07.003--
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