Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tirofiban
Drug ID BADD_D02228
Description Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation.
Indications and Usage For treatment, in combination with heparin, of acute coronary syndrome, including patients who are to be managed medically and those undergoing PTCA or atherectomy.
Marketing Status approved
ATC Code B01AC17
DrugBank ID DB00775
KEGG ID D08607
MeSH ID D000077466
PubChem ID 60947
TTD Drug ID D0BN9X
NDC Product Code 68083-145; 25208-001; 25208-002; 55150-430; 55150-429; 25208-901; 25208-902
UNII GGX234SI5H
Synonyms Tirofiban | N-(Butylsulfonyl)-O-(4-(4-piperidyl)butyl)-L-tyrosine | Aggrastat | Agrastat | MK 383 | MK-383 | L 700462 | L-700462 | L-700,462 | L 700,462 | L700,462 | Tirofiban Hydrochloride | Tirofiban Hydrochloride Monohydrate
Chemical Information
Molecular Formula C22H36N2O5S
CAS Registry Number 144494-65-5
SMILES CCCCS(=O)(=O)NC(CC1=CC=C(C=C1)OCCCCC2CCNCC2)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acute respiratory failure14.01.04.004; 22.02.06.0010.003742%-
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Angina pectoris02.02.02.002; 24.04.04.0020.001193%
Arterial thrombosis24.01.01.0020.000082%-
Bradycardia02.03.02.002---
Cardiac failure02.05.01.0010.001069%
Cardiac failure acute02.05.01.0050.003701%-
Cerebral haemorrhage17.08.01.003; 24.07.04.0010.000822%-
Chills08.01.09.001; 15.05.03.016--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Extradural haematoma12.01.10.002; 17.08.05.001; 24.07.04.002---
Gingival bleeding07.09.07.001; 24.07.02.0100.000419%-
Haematocrit decreased13.01.05.001---
Haematoma24.07.01.0010.000222%
Haemoglobin decreased13.01.05.003---
Haemorrhage intracranial17.08.01.008; 24.07.04.0030.004606%
Hyperhidrosis08.01.03.028; 23.02.03.004--
Myocardial infarction02.02.02.007; 24.04.04.0090.001110%
Oedema08.01.07.006; 14.05.06.010---
Pain in extremity15.03.04.010--
Pelvic pain07.01.06.012; 20.02.03.007; 21.10.01.001--
Pericardial haemorrhage02.06.01.003; 24.07.01.013---
Platelet count decreased13.01.04.001--
Presyncope02.11.04.013; 17.02.05.009; 24.06.02.010--
Pulmonary alveolar haemorrhage22.01.02.005; 24.07.01.0150.000082%-
Pulmonary haemorrhage22.12.01.009; 24.07.01.016--
Pyrexia08.05.02.003--
Retroperitoneal haemorrhage07.07.02.002; 12.01.17.018; 24.07.01.017--
Thrombocytopenia01.08.01.0020.009253%-
Ureteric obstruction20.06.01.005---
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ADReCS-Target
Drug Name ADR Term Target
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