Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Theophylline
Drug ID BADD_D02195
Description A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly for asthma, bronchospasm, and COPD.
Indications and Usage For the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, such as emphysema and chronic bronchitis.
Marketing Status approved
ATC Code R03DA04
DrugBank ID DB00277
KEGG ID D00371; D06103
MeSH ID D013806
PubChem ID 2153
TTD Drug ID D0F8RA
NDC Product Code 29033-001; 54838-556; 60687-258; 62135-556; 0480-3310; 69315-227; 62135-457; 23155-741; 46708-025; 68462-356; 62332-025; 68462-380; 69315-226; 72162-2038; 27808-033; 58624-0401; 51407-318; 68462-721; 68462-722; 0480-3309; 46708-026; 60219-2045; 49452-7720; 42291-922; 42858-702; 60219-2046; 38779-1816; 23155-742; 29033-002; 0121-4820; 42858-701; 62332-026; 60592-073; 0121-0820; 65724-4203; 51407-319
UNII C137DTR5RG
Synonyms Theophylline | 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione | 1,3-Dimethylxanthine | 1,3 Dimethylxanthine | Armophylline | Constant-T | Constant T | ConstantT | Elixophyllin | Euphylong | Glycine Theophyllinate | Theophyllinate, Glycine | Lodrane | Uniphyllin | Nuelin S.A. | Nuelin | Monospan | Quibron T-SR | Quibron T SR | Quibron TSR | Slo-Phyllin | Slo Phyllin | SloPhyllin | Somophyllin-T | Somophyllin T | SomophyllinT | Sustaire | Synophylate | Theo Von Ct | Ct, Theo Von | Von Ct, Theo | Theo-24 | Theo 24 | Theo24 | Theobid | Theocin | Theoconfin Continuous | Theodur | Theo-Dur | Theo Dur | Theolair | Theolix | Theon | Aerolate | Theonite | Theopek | Theophylline Sodium Glycinate | Glycinate, Theophylline Sodium | Sodium Glycinate, Theophylline | Theospan | Theostat | Theovent | Uniphyl | Uniphylline | Theophylline Anhydrous | Anhydrous, Theophylline | Accurbron | Aerobin | Afonilum Retard | Aquaphyllin | Bronchoparat | Bronkodyl
Chemical Information
Molecular Formula C7H8N4O2
CAS Registry Number 58-55-9
SMILES CN1C2=C(C(=O)N(C1=O)C)NC=N2
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Acid base balance abnormal13.02.01.001---
Agitation17.02.05.012; 19.06.02.001--
Albuminuria20.02.01.001---
Alopecia23.02.02.001--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Anaphylactic shock10.01.07.002; 24.06.02.004---
Anaphylactoid reaction10.01.07.003; 24.06.03.007---
Anxiety19.06.02.002--
Arrhythmia02.03.02.001---
Asthenia08.01.01.001---
Asthma10.01.03.010; 22.03.01.002---
Atrial fibrillation02.03.03.002--
Atrial flutter02.03.03.003--
Atrial tachycardia02.03.03.004--
Blood uric acid increased13.02.04.001---
Body temperature increased13.15.01.001---
Bronchospasm10.01.03.012; 22.03.01.004--
Cardiac arrest02.03.04.001--
Cardio-respiratory arrest02.03.04.002; 22.02.06.007---
Circulatory collapse24.06.02.001---
Coma17.02.09.001---
Completed suicide08.04.01.010; 19.12.01.001---
Cough22.02.03.001--
Cyanosis02.11.04.004; 22.02.02.007; 23.06.04.005; 24.03.01.007--
Death08.04.01.001--
Dermatitis23.03.04.002---
Dermatitis contact10.01.01.003; 12.03.01.040; 23.03.04.004---
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ADReCS-Target
Drug Name ADR Term Target
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