Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tetrofosmin
Drug ID BADD_D02190
Description Tetrofosmin was developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic compounds. It presents a molecular formula of 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane. Tetrofosmin is part of the group of diphosphines. Tetrofosmin is used in conjunction with technetium Tc-99m as a radiopharmaceutical.[A7788]
Indications and Usage Tetrofosmin is indicated to be used as a complex with technetium Tc-99m for scintigraphic imaging of the myocardium following separate administrations under exercise and/or resting conditions. It helps in the delineation of regions of reversible myocardial ischemia in absence of infarcted myocardium.[L2001] This complex is also used for scintigraphic imaging of the myocardium to identify changes in perfusion induced by pharmacologic stress in patients with known or suspected coronary artery disease.[L2001] This complex is indicated for the assessment of left ventricular function in patients evaluated for heart disease.[L2001]
Marketing Status approved
ATC Code Not Available
DrugBank ID DB11180
KEGG ID D06094
MeSH ID C078700
PubChem ID 4274
TTD Drug ID D05HFN
NDC Product Code 17156-024; 17156-026; 71806-026
UNII 3J0KPB596Q
Synonyms technetium tc-99m tetrofosmin | technetium-99m-tetrofosmin | technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane | 99mTc-tetrafosmin | 99mTc-tetrofosmin | Tc-99m-tetrofosmin | technetium(1+)-99tc, bis(6,9-bis(2-ethoxyethyl)-3,12-dioxa-6,9-diphosphatetradecane-.kappa.p,.kappa.p')dioxo-, (oc-6-11)- | Myoview | PPN-1011 | Tc-99m-PPN1011 | PPN1011
Chemical Information
Molecular Formula C18H40O4P2
CAS Registry Number 127502-06-1
SMILES CCOCCP(CCOCC)CCP(CCOCC)CCOCC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001---
Abdominal pain07.01.05.002--
Angina pectoris02.02.02.002; 24.04.04.002--
Anxiety19.06.02.002-
Arrhythmia02.03.02.001---
Asthenia08.01.01.001---
Body temperature increased13.15.01.001---
Bronchospasm10.01.03.012; 22.03.01.004--
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003--
Chills08.01.09.001; 15.05.03.016-
Cough22.02.03.001--
Dermatitis23.03.04.002---
Dermatitis allergic10.01.03.014; 23.03.04.003---
Dermatitis atopic10.01.04.004; 23.03.04.016---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007-
Drug ineffective08.06.01.006--
Dysgeusia07.14.03.001; 17.02.07.003--
Dyspnoea02.11.05.003; 22.02.01.004--
Electrocardiogram abnormal13.14.05.001---
Erythema23.03.06.001--
Extravasation08.01.03.008--
Feeling abnormal08.01.09.014--
Feeling cold08.01.09.008--
Flushing08.01.03.025; 23.06.05.003; 24.03.01.002--
Gait disturbance08.01.02.002; 15.03.05.013; 17.02.05.016-
Gastrointestinal pain07.01.05.005--
Headache17.14.01.001-
Hyperhidrosis08.01.03.028; 23.02.03.004-
Hypersensitivity10.01.03.003-
Hypertension24.08.02.001-
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