Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tetracycline
Drug ID BADD_D02179
Description Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane causing intracellular components to leak from bacterial cells.
Indications and Usage Used to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, tick fevers, Q fever, rickettsialpox and Brill-Zinsser disease. May be used to treat infections caused by Chlamydiae spp., B. burgdorferi (Lyme disease), and upper respiratory infections caused by typical (S. pneumoniae, H. influenzae, and M. catarrhalis) and atypical organisms (C. pneumoniae, M. pneumoniae, L. pneumophila). May also be used to treat acne. Tetracycline may be an alternative drug for people who are allergic to penicillin.
Marketing Status approved; vet_approved
ATC Code A01AB13; D06AA04; J01AA07; S01AA09; S02AA08; S03AA02
DrugBank ID DB00759
KEGG ID D00201
MeSH ID D013752
PubChem ID 54675776
TTD Drug ID D08NQZ
NDC Product Code Not Available
UNII F8VB5M810T
Synonyms Tetracycline | Tetrabid | 4-Epitetracycline | 4 Epitetracycline | Topicycline | Achromycin V | Hostacyclin | Tetracycline Hydrochloride | Tetracycline Monohydrochloride | Sustamycin | Achromycin
Chemical Information
Molecular Formula C22H24N2O8
CAS Registry Number 60-54-8
SMILES CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypoaesthesia oral07.05.05.003; 17.02.06.021---
Inflammation08.01.05.007; 10.02.01.089---
Decreased appetite08.01.09.028; 14.03.01.005--
Renal impairment20.01.03.010---
Anal pruritus07.03.03.002---
Oropharyngeal pain07.05.05.004; 22.12.03.016--
Acute kidney injury20.01.03.016--
Candida infection11.03.03.021--
Fixed eruption08.01.06.025; 10.01.01.037; 23.03.05.008---
Pharyngeal swelling22.04.05.028---
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