| Pharmaceutical Information |
| Drug Name |
Tetracycline |
| Drug ID |
BADD_D02179 |
| Description |
Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane causing intracellular components to leak from bacterial cells. |
| Indications and Usage |
Used to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, tick fevers, Q fever, rickettsialpox and Brill-Zinsser disease. May be used to treat infections caused by Chlamydiae spp., B. burgdorferi (Lyme disease), and upper respiratory infections caused by typical (S. pneumoniae, H. influenzae, and M. catarrhalis) and atypical organisms (C. pneumoniae, M. pneumoniae, L. pneumophila). May also be used to treat acne. Tetracycline may be an alternative drug for people who are allergic to penicillin. |
| Marketing Status |
approved; vet_approved |
| ATC Code |
A01AB13; D06AA04; J01AA07; S01AA09; S02AA08; S03AA02 |
| DrugBank ID |
DB00759
|
| KEGG ID |
D00201
|
| MeSH ID |
D013752
|
| PubChem ID |
54675776
|
| TTD Drug ID |
D08NQZ
|
| NDC Product Code |
Not Available |
| UNII |
F8VB5M810T
|
| Synonyms |
Tetracycline | Tetrabid | 4-Epitetracycline | 4 Epitetracycline | Topicycline | Achromycin V | Hostacyclin | Tetracycline Hydrochloride | Tetracycline Monohydrochloride | Sustamycin | Achromycin |
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| Chemical Information |
| Molecular Formula |
C22H24N2O8 |
| CAS Registry Number |
60-54-8 |
| SMILES |
CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O |
| Chemical Structure |
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| ADRs Induced by Drug |
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