| Drug Name |
Terbinafine |
| Drug ID |
BADD_D02160 |
| Description |
Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues.[A1279] Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epoxidase), an enzyme that is part of the fungal cell wall synthesis pathway.[A1279,A1281,L9068]
Terbinafine hydrochloride was granted FDA approval on 30 December 1992.[L9064] |
| Indications and Usage |
Terbinafine hydrochloride is indicated to treat fungal skin and nail infections caused by _Trichophyton_ species, _Microsporum canis_, _Epidermophyton floccosum_,[L9068] and _Tinea_ species.[L9065] Terbinafine hydrochloride also treats yeast infections of the skin caused by _Candida_ species and _Malassezia furfur_.[L9068] |
| Marketing Status |
approved; investigational; vet_approved |
| ATC Code |
D01AE15; D01BA02 |
| DrugBank ID |
DB00857
|
| KEGG ID |
D02375
|
| MeSH ID |
D000077291
|
| PubChem ID |
1549008
|
| TTD Drug ID |
D01AYJ
|
| NDC Product Code |
71205-152; 71335-1668; 69097-859; 62135-572; 63187-213; 76282-209; 72189-243; 59349-0008; 70518-1191 |
| UNII |
G7RIW8S0XP
|
| Synonyms |
Terbinafine | Terbinafine, (Z)-isomer | Terbinafine, (Z)- | Lamisil | (E)-N-(6,6-Dimethyl-2-heptenynyl)-N-methyl-1-naphthalenementhamin hydrochloride | TDT-067 | TDT 067 | TDT067 | DA 5505 | SF 86-327 | SF 86 327 | SF 86327 | SF-86-327 | SF86327 | Terbinafine Hydrochloride |
