Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Temsirolimus
Drug ID BADD_D02151
Description Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. Temsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agency (EMEA) on November 2007.
Indications and Usage For the treatment of renal cell carcinoma (RCC). Also investigated for use/treatment in breast cancer, lymphoma (unspecified), rheumatoid arthritis, and multiple myeloma.
Marketing Status approved
ATC Code L01EG01
DrugBank ID DB06287
KEGG ID D06068
MeSH ID C401859
PubChem ID 6918289
TTD Drug ID D0ES1Q
NDC Product Code 0008-1179; 65219-200; 16729-223; 68254-6237; 78848-002; 65727-047
UNII 624KN6GM2T
Synonyms temsirolimus | rapamycin, 42-(3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate) | CCI 779 | CCI-779 | Torisel
Chemical Information
Molecular Formula C56H87NO16
CAS Registry Number 162635-04-3
SMILES CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O) C(C)CC4CCC(C(C4)OC)OC(=O)C(C)(CO)CO)C)C)O)OC)C)C)C)OC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypophosphataemia14.04.03.001--
Immune system disorder10.02.01.001---
Impaired healing08.03.02.001---
Infection11.01.08.002---
Influenza11.05.03.001; 22.07.02.001---
Insomnia17.15.03.002; 19.02.01.002--
Interstitial lung disease10.02.01.033; 22.01.02.003---
Intestinal perforation07.04.06.002---
Lacrimation disorder06.08.02.010---
Laryngitis11.01.13.001; 22.07.03.001--
Leukopenia01.02.02.001---
Lung disorder22.02.07.001---
Lymphocyte count decreased13.01.06.006--
Lymphopenia01.02.02.002---
Mouth haemorrhage07.05.02.001; 24.07.02.014--
Mouth ulceration07.05.06.004---
Mucosal inflammation08.01.06.002---
Myalgia15.05.02.001--
Nail disorder23.02.05.002--
Nausea07.01.07.001--
Nervous system disorder17.02.10.001---
Neutropenia01.02.03.004---
Neutrophil count decreased13.01.06.010--
Oedema08.01.07.006; 14.05.06.010---
Oedema genital21.10.01.011--
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.011--
Ophthalmic herpes zoster06.04.05.023; 11.05.02.021; 17.04.08.005---
Oral pain07.05.05.034--
Pain08.01.08.004--
Pericardial effusion02.06.01.002--
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ADReCS-Target
Drug Name ADR Term Target
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