Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tamoxifen citrate
Drug ID BADD_D02112
Description Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment for these types of cancers as patients generally have better survival, side effect profiles, and compliance with [anastrozole].[A1026] Tamoxifen was granted FDA approval on 30 December 1977.[L7799]
Indications and Usage Tamoxifen is indicated for the treatment of metastatic breast cancer in women and men and ductal carcinoma in Situ.
Marketing Status Prescription; Discontinued
ATC Code L02BA01
DrugBank ID DB00675
KEGG ID D00966
MeSH ID D013629
PubChem ID 2733525
TTD Drug ID D07KSG
NDC Product Code 89141-123; 65319-1051; 63275-9865; 63187-976; 51407-440; 60429-910; 63739-269; 68071-5005; 59651-300; 50090-0942; 70771-1185; 71335-1424; 0591-2472; 68382-827; 0378-0144; 63739-143; 65319-1151; 46014-1180; 59651-299; 13632-654; 51927-5076; 0378-0274; 71335-0893; 51927-2976; 51407-439; 17337-0035; 51552-0838; 60429-909; 51862-642; 46014-1200; 51862-447; 51862-446; 0591-2473; 51862-682; 68382-826; 17337-0034; 51862-643; 50090-0485; 71335-0237; 46014-1190; 49452-7571; 70518-2721; 36974-0048; 46014-1015; 70771-1184
Synonyms Tamoxifen | ICI-47699 | ICI 47699 | ICI47699 | Nolvadex | Novaldex | Tamoxifen Citrate | Citrate, Tamoxifen | Tomaxithen | Zitazonium | ICI-46474 | ICI 46474 | ICI46474 | ICI-46,474 | ICI 46,474 | ICI46,474 | Soltamox
Chemical Information
Molecular Formula C32H37NO8
CAS Registry Number 54965-24-1
SMILES CCC(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O) O
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Adenocarcinoma16.16.01.004--Not Available
Ageusia07.14.03.003; 17.02.07.001--Not Available
Alanine aminotransferase increased13.03.01.003--
Alopecia23.02.02.001--
Amenorrhoea05.05.01.002; 21.01.02.001--
Anaemia01.03.02.001--
Angina pectoris02.02.02.002; 24.04.04.002--
Angioedema10.01.05.009; 23.04.01.001--Not Available
Anxiety19.06.02.002--
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Arthropathy15.01.01.003--Not Available
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.001--Not Available
Back pain15.03.04.005--
Blindness06.02.02.001; 17.17.01.003--Not Available
Blister12.01.06.002; 23.03.01.001--Not Available
Blood bilirubin increased13.03.01.008--
Blood creatine increased13.13.01.001--Not Available
Blood creatinine increased13.13.01.004--
Blood triglycerides increased13.12.03.001--Not Available
Bone pain15.02.01.001--
Breast feeding26.05.01.001--Not Available
Breast neoplasm16.10.02.001; 21.05.01.004--Not Available
Breast pain21.05.05.003--
Bronchitis11.01.09.001; 22.07.01.001--
Cardiovascular disorder02.01.01.001; 24.03.02.009--Not Available
The 1th Page    1 2 3 4 5    Next   Last    Total 7 Pages