Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tafluprost
Drug ID BADD_D02108
Description A prostaglandin analogue ester prodrug used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. Chemically, tafluprost is a fluorinated analog of prostaglandin F2-alpha. Tafluprost was approved for use in the U.S. on February 10, 2012.
Indications and Usage Tafluprost is indicated for reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Marketing Status approved
ATC Code S01EE05
DrugBank ID DB08819
KEGG ID D06274
MeSH ID C485333
PubChem ID 9868491
TTD Drug ID D04LCQ
NDC Product Code 82584-609; 61556-080; 65035-137; 54893-0021; 63190-0590; 76397-013; 65302-062; 68245-0012; 75872-0001; 66993-429; 0781-6184; 70390-0001; 17478-609
UNII 1O6WQ6T7G3
Synonyms tafluprost | 1-methylethyl (5Z)-7-((1R,2R, 3R,5S)-2-((1E)-3,3-difluoro-4-phenoxy -1-butenyl)-3,5-dihydroxycyclopentyl)-5-heptenoate | AFP-168
Chemical Information
Molecular Formula C25H34F2O5
CAS Registry Number 209860-87-7
SMILES CC(C)OC(=O)CCCC=CCC1C(CC(C1C=CC(COC2=CC=CC=C2)(F)F)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Lacrimation increased06.08.02.0040.001462%
Lymphoma01.12.01.001; 16.20.01.0010.000107%-
Macular oedema06.04.06.0050.000107%-
Muscle spasms15.05.03.0040.000365%
Myocardial infarction02.02.02.007; 24.04.04.0090.000161%
Nasopharyngitis11.01.13.002; 22.07.03.002---
Neoplasm malignant16.16.01.0010.000161%-
Nervous system disorder17.02.10.001---
Ocular hyperaemia06.04.05.0040.010102%-
Photophobia06.01.01.004; 17.17.02.0060.001698%
Pruritus23.03.12.0010.000473%
Punctate keratitis06.04.02.003---
Retinal detachment06.09.03.003; 12.01.04.0040.000161%
Rhinitis11.01.13.004; 22.07.03.006--
Skin discolouration23.03.03.0050.000365%-
Tinnitus04.04.01.002; 17.04.07.0040.000419%
Urinary tract infection11.01.14.004; 20.08.02.001--
Uveitis06.04.03.003; 10.02.01.023--
Vision blurred06.02.06.007; 17.17.01.0100.001150%
Visual acuity reduced06.02.10.012; 17.17.01.0110.000365%
Visual impairment06.02.10.0130.000398%-
Wheezing22.03.01.0090.000236%
Growth of eyelashes06.06.04.0070.000107%-
Iris hyperpigmentation06.06.06.001---
Foreign body sensation in eyes06.01.01.0060.001096%-
Conjunctival hyperaemia06.04.01.0040.000548%-
Eyelids pruritus06.08.03.007; 23.03.12.0050.000731%-
Eye pruritus06.04.05.0060.003708%-
Ocular discomfort06.08.03.0080.000548%-
Eyelid irritation06.04.04.007; 23.03.04.0230.000913%-
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