Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Suvorexant
Drug ID BADD_D02103
Description Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia.
Indications and Usage Suvorexant is indicated for the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance.
Marketing Status approved; investigational
ATC Code N05CM19
DrugBank ID DB09034
KEGG ID D10082
MeSH ID C551624
PubChem ID 24965990
TTD Drug ID D00OVU
NDC Product Code 0006-0325; 0006-0001; 70966-0034; 0006-0003; 50473-0029; 0006-0002; 0006-0033; 0006-0004; 0006-0335; 0006-0005
UNII 081L192FO9
Synonyms suvorexant | (4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone | methanone, ((7R)-4-(5-chloro-2-benzoxazolyl)hexahydro-7-methyl-1H-1,4-diazepin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)- | MK 4305 | MK4305 | MK-4305 | Belsomra
Chemical Information
Molecular Formula C23H23ClN6O2
CAS Registry Number 1030377-33-3
SMILES CC1CCN(CCN1C(=O)C2=C(C=CC(=C2)C)N3N=CC=N3)C4=NC5=C(O4)C=CC(=C5)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Drug ineffective for unapproved indication08.06.01.038; 12.09.02.0020.000954%-
Loss of therapeutic response08.06.01.0410.001111%-
Sleep deficit17.15.04.0100.000287%-
Therapeutic product effect decreased08.06.01.0500.003332%-
Therapeutic product effect delayed08.06.01.0510.001333%-
Therapeutic product effect incomplete08.06.01.0520.005971%-
Therapeutic product ineffective08.06.01.0570.000444%-
Therapeutic response delayed08.06.01.0600.000444%-
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