Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sulfur colloid
Drug ID BADD_D02095
Description Technetium 99m sulfur colloid is a radiopharmaceutical diagnostic agent used in the evaluation of various conditions including lymph node metastases in breast cancer, detection of shunt patency, imaging of reticuloendothelial cells for assessment of liver function, and studies of esophageal transit and gastroesophageal reflux. Following injection or oral administration, single photon emission computer tomography (SPECT) imaging is performed using a gamma camera to detect technetium-99m decay. This is possible as Technetium-99m decays by isomeric transition to technetium-99 through the release of a gamma ray. Depending on site of administration and intended usage, Technetium 99m sulfur colloid enters the capillaries and is transported to the lymph nodes (subcutaneous injection), mixes with peritoneal fluid (intraperitoneal injection), is taken up by reticulocytes (intravenous injection), or enters the gastroesphageal tract (oral administration).
Indications and Usage Technetium 99m sulfur colloid is indicated as a diagnostic agent in adults for the following tests: localization of lymph nodes draining a primary tumor in patients with breast cancer or malignant melanoma; and evaluation of peritoneo-venous (LeVeen) shunt patency. It is indicated in both adult and pediatric patients for: imaging areas of functioning reticuloendothelial cells in the liver, spleen and bone marrow; and studies of esophageal transit and gastroesophageal reflux, and detection of pulmonary aspiration of gastric contents.
Marketing Status approved; investigational
ATC Code Not Available
DrugBank ID DB09397
KEGG ID Not Available
MeSH ID D013671
PubChem ID 76957057
TTD Drug ID Not Available
NDC Product Code Not Available
UNII 556Q0P6PB1
Synonyms Technetium Tc 99m Sulfur Colloid | Tc-99m Sulfur Colloid | Colloid, Tc-99m Sulfur | Technetium Sulfur Colloid | Colloid, Technetium Sulfur | Tc 99m Sulfur Colloid | Lymphoszint
Chemical Information
Molecular Formula S8Tc
CAS Registry Number Not Available
SMILES S1SSSSSSS1.[Tc]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Anaphylactic shock10.01.07.002; 24.06.02.004---
Bronchospasm10.01.03.012; 22.03.01.004--
Cardio-respiratory arrest02.03.04.002; 22.02.06.007---
Chills08.01.09.001; 15.05.03.016--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dyspnoea02.11.05.003; 22.02.01.004--
Erythema23.03.06.001---
Flushing08.01.03.025; 23.06.05.003; 24.03.01.002--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hypersensitivity10.01.03.003--
Hypoaesthesia17.02.06.023; 23.03.03.081---
Hypotension24.06.03.002--
Injection site reaction08.02.03.014; 12.07.03.015--
Multiple sclerosis10.04.10.008; 17.16.01.001---
Nausea07.01.07.001--
Pain08.01.08.004--
Pallor08.01.03.032; 23.03.03.031; 24.03.04.001---
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
Rash23.03.13.001---
Scar12.01.06.008; 23.03.11.008---
Seizure17.12.03.001--
Swelling08.01.03.015---
Urticaria10.01.06.001; 23.04.02.001--
Vomiting07.01.07.003--
Eschar12.01.08.008; 23.03.03.027; 24.04.03.024---
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