Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sugammadex
Drug ID BADD_D02084
Description Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery in adults. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general anesthesia, ventilation, or tracheal intubation that patients may require for surgery. Sugammadex provides a new treatment option to reverse the effects of those medications and possibly help patients recover sooner post-surgery. Sugammadex (brand name Bridion) is marketed by Merck Sharp and Dohme, and was approved by the United States FDA on December 15, 2015.
Indications and Usage Sugammadex is indicated for the reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide in adults undergoing surgery.
Marketing Status approved
ATC Code V03AB35
DrugBank ID DB06206
KEGG ID D05940
MeSH ID D000077122
PubChem ID 6918585
TTD Drug ID D08RID
NDC Product Code 58175-0618; 17404-1030; 48087-0151; 60870-0464; 31722-254; 63552-003; 0006-5425; 48087-0153; 0006-5423; 71872-7187; 63552-004; 31722-255
UNII 361LPM2T56
Synonyms Sugammadex | Org 25969 | Sugammadex Sodium | 6-Perdeoxy-6-per(2-carboxyethyl)thio-gamma-cyclodextrin sodium salt | Bridion
Chemical Information
Molecular Formula C72H112O48S8
CAS Registry Number 343306-71-8
SMILES C(CSCC1C2C(C(C(O1)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)OC5C(OC(C(C5O)O)OC6C(OC(C(C6O) O)OC7C(OC(C(C7O)O)OC8C(OC(C(C8O)O)OC9C(OC(O2)C(C9O)O)CSCCC(=O)O)CSCCC(=O)O)CSCCC (=O)O)CSCCC(=O)O)CSCCC(=O)O)CSCCC(=O)O)CSCCC(=O)O)O)O)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Acute pulmonary oedema02.05.02.004; 22.01.03.0050.001239%-
Anaphylactic reaction10.01.07.001; 24.06.03.0060.035810%
Anaphylactic shock10.01.07.002; 24.06.02.0040.015489%-
Anaphylactoid reaction10.01.07.003; 24.06.03.007---
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.0010.006815%-
Anxiety19.06.02.002--
Arrhythmia02.03.02.0010.001239%-
Atrial fibrillation02.03.03.0020.001239%
Atrioventricular block02.03.01.002---
Atrioventricular block complete02.03.01.0030.002478%
Blood creatine phosphokinase increased13.04.01.001--
Bradycardia02.03.02.0020.035315%-
Bronchospasm10.01.03.012; 22.03.01.0040.022676%
Cardiac arrest02.03.04.0010.021065%
Cardiac failure congestive02.05.01.0020.001239%-
Cardio-respiratory arrest02.03.04.002; 22.02.06.0070.003717%-
Chills08.01.09.001; 15.05.03.016--
Circulatory collapse24.06.02.0010.001239%-
Coma17.02.09.0010.001239%-
Cough22.02.03.0010.004337%
Cyanosis02.11.04.004; 22.02.02.007; 23.06.04.005; 24.03.01.0070.001859%
Depression19.15.01.001--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Drug hypersensitivity10.01.01.0010.008798%-
Drug interaction08.06.03.0010.001859%-
Dry mouth07.06.01.002--
Dyspnoea02.11.05.003; 22.02.01.0040.010780%
Electrocardiogram ST segment abnormal13.14.05.017---
Erythema23.03.06.0010.005576%-
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