Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Sevoflurane
Drug ID BADD_D02015
Description Sevoflurane, also called fluoromethyl, is an ether inhalation anaesthetic agent used for the induction and maintenance of general anesthesia. It is a volatile, non-flammable, non-irritant, and easy-to-administer compound with a low solubility profile and blood-to-gas partition coefficient.
Indications and Usage Used for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.
Marketing Status Prescription
ATC Code N01AB08
DrugBank ID DB01236
KEGG ID D00547
MeSH ID D000077149
PubChem ID 5206
TTD Drug ID D0W6ZF
NDC Product Code 0074-4456; 10019-651; 0781-6160; 12164-005; 66794-015; 66794-022; 54122-4486; 10019-653; 42677-110; 66794-012; 57884-0036; 12164-009
Synonyms Sevoflurane | Fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl)ethyl Ether | Fluoromethyl Hexafluoroisopropyl Ether | Sevorane | Ultane | BAX 3084
Chemical Information
Molecular Formula C4H3F7O
CAS Registry Number 28523-86-6
SMILES C(OC(C(F)(F)F)C(F)(F)F)F
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Acidosis14.01.03.0020.001576%
Aggression19.05.01.0010.002364%Not Available
Agitation17.02.05.012; 19.06.02.0010.001182%
Alanine aminotransferase increased13.03.01.0030.000788%
Albuminuria20.02.01.001--Not Available
Amblyopia06.02.01.001--Not Available
Amnesia17.03.02.001; 19.20.01.0010.001576%
Anaesthetic complication neurological12.02.12.009; 17.02.10.0150.024827%Not Available
Anaphylactic reaction10.01.07.001; 24.06.03.0060.000788%
Anaphylactic shock10.01.07.002; 24.06.02.004--Not Available
Anaphylactoid reaction10.01.07.003; 24.06.03.007--Not Available
Anuria20.01.03.0020.000788%Not Available
Apnoea22.02.01.0010.000788%
Arrhythmia02.03.02.001--Not Available
Arrhythmia supraventricular02.03.03.001--Not Available
Arteriospasm coronary02.02.02.005; 24.04.04.0050.000788%Not Available
Aspartate aminotransferase increased13.03.01.0060.000788%
Asthenia08.01.01.001--Not Available
Atelectasis22.01.02.0010.001182%
Athetosis17.01.01.004--Not Available
Atrial fibrillation02.03.03.002--
Atrioventricular block02.03.01.0020.001576%Not Available
Atrioventricular block complete02.03.01.003--
Atrioventricular block second degree02.03.01.005--
Bacteraemia11.01.11.0010.002364%
Blood alkaline phosphatase13.04.02.010--Not Available
Blood bilirubin increased13.03.01.0080.002364%
Blood creatinine13.13.01.020--Not Available
Blood lactate dehydrogenase increased13.04.02.002--
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ADReCS-Target
Drug Name ADR Term Target
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