Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sertraline
Drug ID BADD_D02010
Description Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Indications and Usage Sertraline is indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD).[L9016] Common off-label uses for sertraline include the prevention of post stroke depression[A187078], generalized anxiety disorder (GAD), fibromyalgia, premature ejaculation, migraine prophylaxis, diabetic neuropathy, and neurocardiogenic syncope.[L5227]
Marketing Status approved
ATC Code N06AB06
DrugBank ID DB01104
KEGG ID D02360
MeSH ID D020280
PubChem ID 68617
TTD Drug ID D0K0TC
NDC Product Code 76282-214; 23155-759; 68180-353; 55700-225; 63187-055; 70518-0153; 70518-1461; 70518-1617; 71335-9714; 0615-7990; 65427-009; 55154-3570; 0615-7991; 76282-212; 0904-6924; 50090-5848; 70518-1040; 23155-757; 70518-2512; 0904-6925; 68180-351; 68180-352; 68071-4400; 63187-212; 68788-7329; 0615-7989; 0904-6926; 55154-3569; 63187-478; 67296-1199; 70934-958; 76282-213; 23155-758; 50090-0989
UNII QUC7NX6WMB
Synonyms Sertraline | Zoloft | Altruline | Lustral | Apo-Sertraline | Apo Sertraline | Aremis | Besitran | Sealdin | Gladem | Novo-Sertraline | Novo Sertraline | ratio-Sertraline | ratio Sertraline | Rhoxal-sertraline | Rhoxal sertraline | Sertraline Hydrochloride | Hydrochloride, Sertraline | Sertraline Hydrochloride (1S-cis)-Isomer | Gen-Sertraline | Gen Sertraline
Chemical Information
Molecular Formula C17H17Cl2N
CAS Registry Number 79617-96-2
SMILES CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Lupus-like syndrome10.04.03.003; 15.06.02.004; 23.03.02.0040.000019%-
Musculoskeletal chest pain15.03.04.012; 22.09.01.0010.000045%
Lower gastrointestinal haemorrhage07.12.03.011; 24.07.02.0300.000032%
Foreign body sensation in eyes06.01.01.0060.000051%-
Self-injurious ideation19.12.01.0070.000140%-
Tonic clonic movements17.12.03.0060.000045%-
Necrotising colitis07.08.01.0130.000019%-
Ear discomfort04.03.01.005---
Ocular discomfort06.08.03.0080.000051%-
Pseudodementia19.20.02.0060.000025%-
Orgasmic sensation decreased19.08.01.003; 21.03.02.0080.000019%-
Periventricular leukomalacia17.13.02.005; 18.04.07.0030.000013%-
Migraine without aura17.14.02.003; 24.03.05.0060.000013%-
Eosinophilic pneumonia acute01.02.04.004; 22.01.01.0080.000032%-
Cardiac flutter02.03.02.0120.000045%-
Coronary artery insufficiency02.02.01.008; 24.04.04.0160.000013%-
Musculoskeletal stiffness15.03.05.0270.000222%-
Epigastric discomfort07.01.02.0040.000038%-
Inappropriate antidiuretic hormone secretion05.03.03.001; 14.05.07.0010.000346%-
Growth retardation05.03.02.007; 14.03.02.031; 15.03.05.0160.000045%
Depressive symptom19.15.02.0030.000025%-
Affect lability19.04.01.001---
Cardiac discomfort02.11.04.0010.000013%-
Vanishing bile duct syndrome09.02.03.0030.000140%-
Skin burning sensation17.02.06.009; 23.03.03.0210.000180%-
Myoclonic epilepsy17.12.03.0070.000019%-
Transaminases increased13.03.04.036---
Cerebral disorder17.02.10.0170.000053%-
Dysphemia17.02.08.010; 19.19.03.0050.000079%-
Foetal death08.04.01.011; 18.01.02.0030.000102%
The 25th Page    First    Pre   25 26 27 28 29    Next   Last    Total 36 Pages
ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene