Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Samarium sm-153 lexidronam
Drug ID BADD_D01985
Description Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium Sm 153 lexidronam is used to help relieve the bone pain that may occur with certain kinds of cancer. The radioactive samarium is taken up in the bone cancer area and gives off radiation that helps provide relief of pain.
Indications and Usage Investigated for use/treatment in bone metastases, multiple myeloma, prostate cancer, and rheumatoid arthritis.
Marketing Status approved; investigational
ATC Code V10BX02
DrugBank ID DB05273
KEGG ID D08504; D05795
MeSH ID C061972
PubChem ID 177960
TTD Drug ID D0R3BC
NDC Product Code Not Available
UNII 745X144DZY
Synonyms samarium Sm-153 lexidronam | samarium-153-EDTMP | 153Sm-EDTMP | samarium-153 lexidronam | samarium (153Sm) lexidronam | samarate(5-)-153Sm, (((1,2-ethanediylbis((nitrilo-kappa-N)bis(methylene)))tetrakis(phosphonato-kappa-O))(8-))-, pentahydrogen, (oc-6-21) | Quadramet | samarium ethylenediaminetetramethylenephosphonate | Sm-EDTMP
Chemical Information
Molecular Formula C6H12N2O12P4Sm-5
CAS Registry Number 154427-83-5
SMILES C(CN(CP(=O)([O-])[O-])CP(=O)([O-])[O-])N(CP(=O)([O-])[O-])CP(=O)([O-])[O-].[Sm+3 ]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Alopecia23.02.02.001--
Angina pectoris02.02.02.002; 24.04.04.002--
Arrhythmia02.03.02.001---
Bronchitis11.01.09.001; 22.07.01.001--
Cardiac failure congestive02.05.01.002---
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Chills08.01.09.001; 15.05.03.016--
Coagulopathy01.01.02.001---
Cough22.02.03.001--
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Ecchymosis01.01.03.001; 23.06.01.001; 24.07.06.002---
Epistaxis22.04.03.001; 24.07.01.005--
Haematuria20.02.01.006; 21.10.01.018; 24.07.01.047--
Haemoglobin decreased13.01.05.003---
Hypertension24.08.02.001--
Hypotension24.06.03.002--
Infection11.01.08.002---
Leukopenia01.02.02.001---
Lymphadenopathy01.09.01.002---
Muscular weakness15.05.06.001; 17.05.03.005--
Nausea07.01.07.001--
Oral candidiasis07.05.07.001; 11.03.03.004---
Pain08.01.08.004--
Paraesthesia17.02.06.005; 23.03.03.094--
Pathological fracture12.04.02.006; 15.08.02.008; 16.32.03.007---
Pneumonia11.01.09.003; 22.07.01.003---
Purpura01.01.04.003; 23.06.01.004; 24.07.06.005--
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